Effect of maturation on the extrathoracic airway stability of infants

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The influence of maturation on extrathoracic airway (ETA) stability during quiet sleep was determined in 13 normal preterm infants of 1.41 ± 0.14 (SD) kg birth weight and 32 ± 2 wk estimated gestational age. Studies began in the first week of life and were performed three times at weekly intervals. A drop in intraluminal pressure within the ETA was produced by external inspiratory flow-resistive loading (60 cmH2O · l-1 · s at 1 l/min); an increase in intrinsic resistance, indicating airway narrowing, was sought as a measure of ETA instability. Baseline total pulmonary resistance was not significantly different between weeks 1, 2, and 3 (88 ± 35, 65 ± 24, and 61 ± 17 cmH2O · l-1 · s, respectively) but increased markedly above baseline with loading to 144 ± 45 cmH2O · l-1 · s during week 1 (P < 0.001), 89 ± 28 cmH2O · l-1 · s at week 2 (P < 0.01), and 74 ± 25 cmH2O · l-1 · s at week 3 (n = 10). The increment with loading was significantly greater during week 1 than during weeks 2 or 3 (P < 0.02). Similar studies were also done in seven full-term infants in the first week of life to evaluate the influence of gestational maturity on ETA stability. Despite a relatively greater drop in intraluminal pressure within the ETA of term vs. preterm infants with loading (P < 0.001), total pulmonary resistance failed to increase (68 ± 21 to 71 ± 32 cmH2O · l-1 · s). These data reveal that ETA instability is present in preterm infants at birth and decreases with increasing postnatal age. Full-term neonates, by comparison, display markedly greater ETA stability in the immediate neonatal period.

Original languageEnglish
Pages (from-to)2368-2372
Number of pages5
JournalJournal of Applied Physiology
Volume73
Issue number6
StatePublished - Dec 1 1992

Fingerprint

Premature Infants
Pressure
Lung
Airway Resistance
Birth Weight
Gestational Age
Sleep
Parturition
Newborn Infant

Keywords

  • loading
  • newborn airway
  • upper airway mechanics

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of maturation on the extrathoracic airway stability of infants. / Duara, Shahnaz; Neto, G. S.; Claure, Nelson R; Gerhardt, T.; Bancalari, Eduardo.

In: Journal of Applied Physiology, Vol. 73, No. 6, 01.12.1992, p. 2368-2372.

Research output: Contribution to journalArticle

@article{42fb97fade9141ee9980ea1278905ab7,
title = "Effect of maturation on the extrathoracic airway stability of infants",
abstract = "The influence of maturation on extrathoracic airway (ETA) stability during quiet sleep was determined in 13 normal preterm infants of 1.41 ± 0.14 (SD) kg birth weight and 32 ± 2 wk estimated gestational age. Studies began in the first week of life and were performed three times at weekly intervals. A drop in intraluminal pressure within the ETA was produced by external inspiratory flow-resistive loading (60 cmH2O · l-1 · s at 1 l/min); an increase in intrinsic resistance, indicating airway narrowing, was sought as a measure of ETA instability. Baseline total pulmonary resistance was not significantly different between weeks 1, 2, and 3 (88 ± 35, 65 ± 24, and 61 ± 17 cmH2O · l-1 · s, respectively) but increased markedly above baseline with loading to 144 ± 45 cmH2O · l-1 · s during week 1 (P < 0.001), 89 ± 28 cmH2O · l-1 · s at week 2 (P < 0.01), and 74 ± 25 cmH2O · l-1 · s at week 3 (n = 10). The increment with loading was significantly greater during week 1 than during weeks 2 or 3 (P < 0.02). Similar studies were also done in seven full-term infants in the first week of life to evaluate the influence of gestational maturity on ETA stability. Despite a relatively greater drop in intraluminal pressure within the ETA of term vs. preterm infants with loading (P < 0.001), total pulmonary resistance failed to increase (68 ± 21 to 71 ± 32 cmH2O · l-1 · s). These data reveal that ETA instability is present in preterm infants at birth and decreases with increasing postnatal age. Full-term neonates, by comparison, display markedly greater ETA stability in the immediate neonatal period.",
keywords = "loading, newborn airway, upper airway mechanics",
author = "Shahnaz Duara and Neto, {G. S.} and Claure, {Nelson R} and T. Gerhardt and Eduardo Bancalari",
year = "1992",
month = "12",
day = "1",
language = "English",
volume = "73",
pages = "2368--2372",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Effect of maturation on the extrathoracic airway stability of infants

AU - Duara, Shahnaz

AU - Neto, G. S.

AU - Claure, Nelson R

AU - Gerhardt, T.

AU - Bancalari, Eduardo

PY - 1992/12/1

Y1 - 1992/12/1

N2 - The influence of maturation on extrathoracic airway (ETA) stability during quiet sleep was determined in 13 normal preterm infants of 1.41 ± 0.14 (SD) kg birth weight and 32 ± 2 wk estimated gestational age. Studies began in the first week of life and were performed three times at weekly intervals. A drop in intraluminal pressure within the ETA was produced by external inspiratory flow-resistive loading (60 cmH2O · l-1 · s at 1 l/min); an increase in intrinsic resistance, indicating airway narrowing, was sought as a measure of ETA instability. Baseline total pulmonary resistance was not significantly different between weeks 1, 2, and 3 (88 ± 35, 65 ± 24, and 61 ± 17 cmH2O · l-1 · s, respectively) but increased markedly above baseline with loading to 144 ± 45 cmH2O · l-1 · s during week 1 (P < 0.001), 89 ± 28 cmH2O · l-1 · s at week 2 (P < 0.01), and 74 ± 25 cmH2O · l-1 · s at week 3 (n = 10). The increment with loading was significantly greater during week 1 than during weeks 2 or 3 (P < 0.02). Similar studies were also done in seven full-term infants in the first week of life to evaluate the influence of gestational maturity on ETA stability. Despite a relatively greater drop in intraluminal pressure within the ETA of term vs. preterm infants with loading (P < 0.001), total pulmonary resistance failed to increase (68 ± 21 to 71 ± 32 cmH2O · l-1 · s). These data reveal that ETA instability is present in preterm infants at birth and decreases with increasing postnatal age. Full-term neonates, by comparison, display markedly greater ETA stability in the immediate neonatal period.

AB - The influence of maturation on extrathoracic airway (ETA) stability during quiet sleep was determined in 13 normal preterm infants of 1.41 ± 0.14 (SD) kg birth weight and 32 ± 2 wk estimated gestational age. Studies began in the first week of life and were performed three times at weekly intervals. A drop in intraluminal pressure within the ETA was produced by external inspiratory flow-resistive loading (60 cmH2O · l-1 · s at 1 l/min); an increase in intrinsic resistance, indicating airway narrowing, was sought as a measure of ETA instability. Baseline total pulmonary resistance was not significantly different between weeks 1, 2, and 3 (88 ± 35, 65 ± 24, and 61 ± 17 cmH2O · l-1 · s, respectively) but increased markedly above baseline with loading to 144 ± 45 cmH2O · l-1 · s during week 1 (P < 0.001), 89 ± 28 cmH2O · l-1 · s at week 2 (P < 0.01), and 74 ± 25 cmH2O · l-1 · s at week 3 (n = 10). The increment with loading was significantly greater during week 1 than during weeks 2 or 3 (P < 0.02). Similar studies were also done in seven full-term infants in the first week of life to evaluate the influence of gestational maturity on ETA stability. Despite a relatively greater drop in intraluminal pressure within the ETA of term vs. preterm infants with loading (P < 0.001), total pulmonary resistance failed to increase (68 ± 21 to 71 ± 32 cmH2O · l-1 · s). These data reveal that ETA instability is present in preterm infants at birth and decreases with increasing postnatal age. Full-term neonates, by comparison, display markedly greater ETA stability in the immediate neonatal period.

KW - loading

KW - newborn airway

KW - upper airway mechanics

UR - http://www.scopus.com/inward/record.url?scp=0027051627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027051627&partnerID=8YFLogxK

M3 - Article

C2 - 1490945

AN - SCOPUS:0027051627

VL - 73

SP - 2368

EP - 2372

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -