TY - JOUR
T1 - Effect of lurasidone dose on cognition in patients with schizophrenia
T2 - Post-hoc analysis of a long-term, double-blind continuation study
AU - Harvey, Philip D.
AU - Siu, Cynthia O.
AU - Ogasa, Masaaki
AU - Loebel, Antony
N1 - Funding Information:
This study was sponsored by Sunovion Pharmaceuticals Inc. The sponsor was involved in the study design and collection of data.
PY - 2015
Y1 - 2015
N2 - We previously reported that treatment with 160 mg/d of lurasidone improved cognitive performance in a manner superior to placebo, quetiapine XR 600 mg/d, and lurasidone 80 mg/d, based on a 6-week randomized trial of patients with an acute exacerbation of schizophrenia. The objective of this post-hoc analysis was to explore the cognitive and functional performance of patients whose final doses of lurasidone were 40/80 mg/d, 120 mg/d, and 160 mg/d compared to quetiapine XR 200-800 mg/d (QXR) during a 6-month, double-blind continuation study that followed a short-term trial. Subjects who received final doses of lurasidone 120. mg/d (n = 77) and 160 mg/d (n = 49) showed significantly greater improvement in overall cognitive performance compared to QXR (n = 85) at week 32 (month 6 of the extension study), while those on last doses of 40/80 mg/d (n = 25) showed a trend towards significance at week 32. Mean changes in neurocognitive composite z-score from pre-treatment baseline were significant for the 3 lurasidone final dose groups at both weeks 19 and 32, with composite change scores of z = 1.53, z = 1.43, and z = 1.34 for the lurasidone 40/80 mg/d, 120 mg/d, and 160. mg/d, respectively, at week 32. In contrast, the composite change score was not statistically significant in the overall quetiapine group (z = 0.46), with none of the individual quetiapine doses showing any significant improvement. Functional capacity scores improved in all treatment groups. Our findings indicate improved cognitive performance in patients treated with each of the flexible doses of lurasidone 40-160 mg/d, compared to quetiapine XR 200-800 mg/d. All doses of lurasidone were superior to all doses of quetiapine for cognitive performance.
AB - We previously reported that treatment with 160 mg/d of lurasidone improved cognitive performance in a manner superior to placebo, quetiapine XR 600 mg/d, and lurasidone 80 mg/d, based on a 6-week randomized trial of patients with an acute exacerbation of schizophrenia. The objective of this post-hoc analysis was to explore the cognitive and functional performance of patients whose final doses of lurasidone were 40/80 mg/d, 120 mg/d, and 160 mg/d compared to quetiapine XR 200-800 mg/d (QXR) during a 6-month, double-blind continuation study that followed a short-term trial. Subjects who received final doses of lurasidone 120. mg/d (n = 77) and 160 mg/d (n = 49) showed significantly greater improvement in overall cognitive performance compared to QXR (n = 85) at week 32 (month 6 of the extension study), while those on last doses of 40/80 mg/d (n = 25) showed a trend towards significance at week 32. Mean changes in neurocognitive composite z-score from pre-treatment baseline were significant for the 3 lurasidone final dose groups at both weeks 19 and 32, with composite change scores of z = 1.53, z = 1.43, and z = 1.34 for the lurasidone 40/80 mg/d, 120 mg/d, and 160. mg/d, respectively, at week 32. In contrast, the composite change score was not statistically significant in the overall quetiapine group (z = 0.46), with none of the individual quetiapine doses showing any significant improvement. Functional capacity scores improved in all treatment groups. Our findings indicate improved cognitive performance in patients treated with each of the flexible doses of lurasidone 40-160 mg/d, compared to quetiapine XR 200-800 mg/d. All doses of lurasidone were superior to all doses of quetiapine for cognitive performance.
KW - Antipsychotics
KW - Lurasidone
KW - Neurocognition
KW - Quetiapine
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U2 - 10.1016/j.schres.2015.06.008
DO - 10.1016/j.schres.2015.06.008
M3 - Article
C2 - 26117157
AN - SCOPUS:84946482162
VL - 166
SP - 334
EP - 338
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -