Effect of low-dose aspirin on angiotensin II pressor response in human pregnancy

Luis Sanchez-Ramos, Mary Jo O'Sullivan, Jose Garrido-Calderon

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Recent clinical studies have reported a significant reduction in the incidence of pregnancy-induced hypertension after the ingestion of low-dose aspirin. The effect of 80 mg of acetylsalicylic acid on vascular sensitivity to exogenous angiotensin II (Hypertensin, Ciba-Geigy Limited, Basel, Switzerland) was examined in 13 normotensive pregnant patients. The effective pressor dose before treatment (17.4 ± 2.2 ng/kg/min) (mean ± SE) was significantly less (p < 0.001) than that after treatment (35.1 ± 4.2 ng/kg/min). Low-dose aspirin therapy resulted in an enhancement of the pregnancy-acquired refractoriness to angiotensin II. It can be speculated that prostglandin synthetase inhibitors at a low dose may alter the thromboxane A2/prostacyclin ratio in favor of the latter.

Original languageEnglish (US)
Pages (from-to)193-194
Number of pages2
JournalAmerican journal of obstetrics and gynecology
Volume156
Issue number1
DOIs
StatePublished - Jan 1987

Keywords

  • Angiotensin II sensitivity
  • aspirin
  • preeclampsia

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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