Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes

J. D. Pandya, K. R. Dave, S. S. Katyare

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Long-term exposure to AlCl3 resulted in 57% decrease in the total phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%-77% decrease); the extent of decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% and 35% with marginal changes in the phospholipid composition. However, the contents of all phospholipids decreased uniformly by about 70%. The synaptic plasma membranes were more fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.

Original languageEnglish (US)
Pages (from-to)531-539
Number of pages9
JournalJournal of Alzheimer's Disease
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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