Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes

J. D. Pandya; K. R. Dave; S. S. Katyare

doi:10.3233/JAD-2001-3603

Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes

J. D. Pandya, K. R. Dave, S. S. Katyare

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Long-term exposure to AlCl3 resulted in 57% decrease in the total phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%-77% decrease); the extent of decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% and 35% with marginal changes in the phospholipid composition. However, the contents of all phospholipids decreased uniformly by about 70%. The synaptic plasma membranes were more fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.

Original language	English (US)
Pages (from-to)	531-539
Number of pages	9
Journal	Journal of Alzheimer's Disease
Volume	3
Issue number	6
DOIs	https://doi.org/10.3233/JAD-2001-3603
State	Published - Jan 1 2001
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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title = "Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes",

abstract = "Long-term exposure to AlCl3 resulted in 57% decrease in the total phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%-77% decrease); the extent of decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% and 35% with marginal changes in the phospholipid composition. However, the contents of all phospholipids decreased uniformly by about 70%. The synaptic plasma membranes were more fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.",

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AU - Dave, K. R.

AU - Katyare, S. S.

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AB - Long-term exposure to AlCl3 resulted in 57% decrease in the total phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%-77% decrease); the extent of decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% and 35% with marginal changes in the phospholipid composition. However, the contents of all phospholipids decreased uniformly by about 70%. The synaptic plasma membranes were more fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.

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Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain synaptic plasma membranes and microsomes

Abstract

ASJC Scopus subject areas

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