Abstract
Long-term exposure to AlCl3 resulted in 57% decrease in the total phospholipid (TPL) content of synaptic plasma membranes from rat brain with significant decrease in the proportion and content of most of the phospholipid classes (32%-77% decrease); the extent of decreases was of lesser magnitude for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The microsomal TPL and cholesterol (CHL) content decreased by 74% and 35% with marginal changes in the phospholipid composition. However, the contents of all phospholipids decreased uniformly by about 70%. The synaptic plasma membranes were more fluidized in Al fed rats. The results suggest that long-term exposure of rats to Al can alter the structure/function of synaptic plasma membranes and microsomes.
Original language | English (US) |
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Pages (from-to) | 531-539 |
Number of pages | 9 |
Journal | Journal of Alzheimer's Disease |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Jan 1 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health