Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain myelin

Jignesh D. Pandya, Kunjan R. Dave, Surendra S. Katyare

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Effect of long-term (90-100 days) exposure of rats to soluble salt of aluminum (AlCl3) on myelin lipid profile was examined. The long-term exposure to AlCl3 resulted in a 60 % decrease in the total phospholipid (TPL) content while the cholesterol (CHL) content increased by 55%. Consequently the TPL/CHL molar ratio decreased significantly by 62%. The phospholipid composition of the myelin membrane changed drastically; the proportion of practically all the phospholipid classes decreased by 32 to 60% except for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Of the latter two, proportion of PC was unchanged while PE increased in proportion by 47%. Quantitatively, all phospholipid classes decreased by from 42 to 76% with no change in the PE content. However the membrane fluidity was not altered in Al-treated rats. Many of the changes we observe here show striking similarities with the reported phospholipid profiles of Alzheimer brains.

Original languageEnglish (US)
Article number13
JournalLipids in Health and Disease
Volume3
DOIs
StatePublished - Jun 22 2004

Keywords

  • Aluminum and myelin lipid
  • Aluminum in Alzheimer etiology
  • Aluminum neurotoxicity
  • Alzheimer's disease
  • Phospholipid profiles

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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