Effect of local radioactivity on tracheal mucous velocity of sheep

T. Ahmed, A. J. Januszkiewicz, J. F. Landa, A. Brown, G. A. Chapman, P. J. Kenny, R. D. Finn, J. Bondick, M. A. Sackner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of local isotope radiation and x-ray radiation on mucociliary transport of sheep were investigated. X-ray radiation from fluoroscopy equivalent to that used to determine tracheal mucous velocity in intact animals (approximately 3 min) did not alter transport of teflon discs in an isolated sheep tracheal preparation. In conscious sheep, 2 ml of a solution containing 8 mCi of macroaggregates of albumin labeled with technetium-99m ( 99mTc) and 99mTc-pyrophosphate and (99m)Tc-pyrophosphate were instilled under direct vision into the trachea via a fiberoptic bronchoscope, providing an actual deposition on the tracheal epithelium of 1.8 to 2 mCi. Physiologic saline and unlabeled macroaggregates of albumin were instilled as control solutions. Tracheal mucous velocity measured by movement of teflon discs increased by 93.2 per cent with 99mTc-labeled macroaggregated albumin and 86.7 per cent with 99mTc-pyrophosphate (P<0.01), but no significant increase occurred after saline or unlabeled macroaggregates of albumin. Discrepancies in the values of tracheal mucous velocity determined using inert particles and radioactive tracer solution or aerosols might be related in part to the local effects of the tracer radiation.

Original languageEnglish
Pages (from-to)567-575
Number of pages9
JournalAmerican Review of Respiratory Disease
Volume120
Issue number3
StatePublished - Dec 1 1979
Externally publishedYes

Fingerprint

Technetium Tc 99m Pyrophosphate
Radioactivity
Albumins
Sheep
X-Rays
Polytetrafluoroethylene
Radiation
Radioactive Tracers
Mucociliary Clearance
Bronchoscopes
Fluoroscopy
Technetium
Radiation Effects
Trachea
Aerosols
Isotopes
Epithelium

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Ahmed, T., Januszkiewicz, A. J., Landa, J. F., Brown, A., Chapman, G. A., Kenny, P. J., ... Sackner, M. A. (1979). Effect of local radioactivity on tracheal mucous velocity of sheep. American Review of Respiratory Disease, 120(3), 567-575.

Effect of local radioactivity on tracheal mucous velocity of sheep. / Ahmed, T.; Januszkiewicz, A. J.; Landa, J. F.; Brown, A.; Chapman, G. A.; Kenny, P. J.; Finn, R. D.; Bondick, J.; Sackner, M. A.

In: American Review of Respiratory Disease, Vol. 120, No. 3, 01.12.1979, p. 567-575.

Research output: Contribution to journalArticle

Ahmed, T, Januszkiewicz, AJ, Landa, JF, Brown, A, Chapman, GA, Kenny, PJ, Finn, RD, Bondick, J & Sackner, MA 1979, 'Effect of local radioactivity on tracheal mucous velocity of sheep', American Review of Respiratory Disease, vol. 120, no. 3, pp. 567-575.
Ahmed T, Januszkiewicz AJ, Landa JF, Brown A, Chapman GA, Kenny PJ et al. Effect of local radioactivity on tracheal mucous velocity of sheep. American Review of Respiratory Disease. 1979 Dec 1;120(3):567-575.
Ahmed, T. ; Januszkiewicz, A. J. ; Landa, J. F. ; Brown, A. ; Chapman, G. A. ; Kenny, P. J. ; Finn, R. D. ; Bondick, J. ; Sackner, M. A. / Effect of local radioactivity on tracheal mucous velocity of sheep. In: American Review of Respiratory Disease. 1979 ; Vol. 120, No. 3. pp. 567-575.
@article{af4413959ef34fd8b657fa553daf059e,
title = "Effect of local radioactivity on tracheal mucous velocity of sheep",
abstract = "The effects of local isotope radiation and x-ray radiation on mucociliary transport of sheep were investigated. X-ray radiation from fluoroscopy equivalent to that used to determine tracheal mucous velocity in intact animals (approximately 3 min) did not alter transport of teflon discs in an isolated sheep tracheal preparation. In conscious sheep, 2 ml of a solution containing 8 mCi of macroaggregates of albumin labeled with technetium-99m ( 99mTc) and 99mTc-pyrophosphate and (99m)Tc-pyrophosphate were instilled under direct vision into the trachea via a fiberoptic bronchoscope, providing an actual deposition on the tracheal epithelium of 1.8 to 2 mCi. Physiologic saline and unlabeled macroaggregates of albumin were instilled as control solutions. Tracheal mucous velocity measured by movement of teflon discs increased by 93.2 per cent with 99mTc-labeled macroaggregated albumin and 86.7 per cent with 99mTc-pyrophosphate (P<0.01), but no significant increase occurred after saline or unlabeled macroaggregates of albumin. Discrepancies in the values of tracheal mucous velocity determined using inert particles and radioactive tracer solution or aerosols might be related in part to the local effects of the tracer radiation.",
author = "T. Ahmed and Januszkiewicz, {A. J.} and Landa, {J. F.} and A. Brown and Chapman, {G. A.} and Kenny, {P. J.} and Finn, {R. D.} and J. Bondick and Sackner, {M. A.}",
year = "1979",
month = "12",
day = "1",
language = "English",
volume = "120",
pages = "567--575",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - Effect of local radioactivity on tracheal mucous velocity of sheep

AU - Ahmed, T.

AU - Januszkiewicz, A. J.

AU - Landa, J. F.

AU - Brown, A.

AU - Chapman, G. A.

AU - Kenny, P. J.

AU - Finn, R. D.

AU - Bondick, J.

AU - Sackner, M. A.

PY - 1979/12/1

Y1 - 1979/12/1

N2 - The effects of local isotope radiation and x-ray radiation on mucociliary transport of sheep were investigated. X-ray radiation from fluoroscopy equivalent to that used to determine tracheal mucous velocity in intact animals (approximately 3 min) did not alter transport of teflon discs in an isolated sheep tracheal preparation. In conscious sheep, 2 ml of a solution containing 8 mCi of macroaggregates of albumin labeled with technetium-99m ( 99mTc) and 99mTc-pyrophosphate and (99m)Tc-pyrophosphate were instilled under direct vision into the trachea via a fiberoptic bronchoscope, providing an actual deposition on the tracheal epithelium of 1.8 to 2 mCi. Physiologic saline and unlabeled macroaggregates of albumin were instilled as control solutions. Tracheal mucous velocity measured by movement of teflon discs increased by 93.2 per cent with 99mTc-labeled macroaggregated albumin and 86.7 per cent with 99mTc-pyrophosphate (P<0.01), but no significant increase occurred after saline or unlabeled macroaggregates of albumin. Discrepancies in the values of tracheal mucous velocity determined using inert particles and radioactive tracer solution or aerosols might be related in part to the local effects of the tracer radiation.

AB - The effects of local isotope radiation and x-ray radiation on mucociliary transport of sheep were investigated. X-ray radiation from fluoroscopy equivalent to that used to determine tracheal mucous velocity in intact animals (approximately 3 min) did not alter transport of teflon discs in an isolated sheep tracheal preparation. In conscious sheep, 2 ml of a solution containing 8 mCi of macroaggregates of albumin labeled with technetium-99m ( 99mTc) and 99mTc-pyrophosphate and (99m)Tc-pyrophosphate were instilled under direct vision into the trachea via a fiberoptic bronchoscope, providing an actual deposition on the tracheal epithelium of 1.8 to 2 mCi. Physiologic saline and unlabeled macroaggregates of albumin were instilled as control solutions. Tracheal mucous velocity measured by movement of teflon discs increased by 93.2 per cent with 99mTc-labeled macroaggregated albumin and 86.7 per cent with 99mTc-pyrophosphate (P<0.01), but no significant increase occurred after saline or unlabeled macroaggregates of albumin. Discrepancies in the values of tracheal mucous velocity determined using inert particles and radioactive tracer solution or aerosols might be related in part to the local effects of the tracer radiation.

UR - http://www.scopus.com/inward/record.url?scp=0018670005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018670005&partnerID=8YFLogxK

M3 - Article

C2 - 484933

AN - SCOPUS:0018670005

VL - 120

SP - 567

EP - 575

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -