Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver

O. P. Sharma, H. P.S. Makkar, Rajinder Dawra

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Oral administration of lantana leaf powder to guinea pigs caused an increase in the hepatic postmitochondrial fraction:homogenate ratios of activities of lysosomal enzymes - acid phosphatase, cathepsin B and DNase II. Enzyme activities of glucokinase, aldolase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase were elevated whereas activity of glutathione-5-transferase decreased. Alterations in the activities of lysosomal and cytosol enzymes appear to constitute an important biochemical lesion in the pathogenesis of guinea pig liver in lantana toxicity.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalToxicology Letters
Volume16
Issue number1-2
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Lantana
Liver
Cytosol
Toxicity
Guinea Pigs
Glucokinase
Cathepsin B
Fructose-Bisphosphate Aldolase
Deoxyribonucleases
Glucosephosphate Dehydrogenase
Enzyme activity
Enzymes
Transferases
Acid Phosphatase
L-Lactate Dehydrogenase
Powders
Glutathione
Glutathione Transferase
Oral Administration

Keywords

  • cytosol enzymes
  • guinea pig liver
  • Lantana toxicity
  • lysosomal enzymes

ASJC Scopus subject areas

  • Toxicology

Cite this

Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver. / Sharma, O. P.; Makkar, H. P.S.; Dawra, Rajinder.

In: Toxicology Letters, Vol. 16, No. 1-2, 01.01.1983, p. 41-45.

Research output: Contribution to journalArticle

Sharma, O. P. ; Makkar, H. P.S. ; Dawra, Rajinder. / Effect of lantana toxicity on lysosomal and cytosol enzymes in guinea pig liver. In: Toxicology Letters. 1983 ; Vol. 16, No. 1-2. pp. 41-45.
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