Effect of Lantana camara toxicity on lipid peroxidation in guinea pig tissues

O. P. Sharma, R. K. Dawra, H. P.S. Makker

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Lantana intoxication of guinea pig inhibited lipid peroxidation in different tissues in the order: adrenals > liver > kidneys > heart > lungs > testes > brain. The inhibitory factor(s) appear to be present in the postmitochondrial fraction. Lantadene A, the toxic principle of lantana plant caused just marginal inhibition of lipid peroxidation in guinea pig liver homogenates. Bilirubin and fraction 'P', a partially purified toxin of Lantana camara are more potent inhibitors of lipid peroxide formation. Lantana toxicity did not affect ascorbic acid, phospholipid content and superoxide dismutase activity of guinea pig liver. The enzyme activity of glutathione peroxidase was significantly elevated.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume38
Issue number1
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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