Effect of Intravitreal Injections on Retinal Imaging Metrics in Glaucomatous and Non-Glaucomatous Eyes

Ronaldo Nuesi, Swarup S. Swaminathan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of Review: To summarize the available literature on retinal imaging metrics in the context of intravitreal injections in glaucomatous and non-glaucomatous eyes. Recent Findings: The retinal nerve fiber layer (RNFL) in injected non-glaucomatous eyes appears to thin at a similar rate to uninjected fellow eyes. A total of four studies evaluating RNFL thinning in injected glaucomatous eyes yielded mixed results, with more recent longitudinal investigations suggesting a potential association. The ganglion cell-inner plexiform layer is also being studied as a potential endpoint in both glaucomatous and non-glaucomatous eyes following intravitreal injections. Summary: There appears to be minimal association between intravitreal injections and RNFL thinning among non-glaucomatous eyes. However, in glaucomatous eyes, fewer studies have been published, and results have varied due to challenges in study design. Additional prospective studies with longer follow-up periods are warranted.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalCurrent Ophthalmology Reports
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2020
Externally publishedYes

Keywords

  • Ganglion cell layer
  • Ganglion cell-inner plexiform layer
  • Glaucoma
  • Intravitreal injections
  • Ocular hypertension
  • Optic nerve
  • Retinal nerve fiber layer

ASJC Scopus subject areas

  • Ophthalmology

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