Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure.

G. J. Candia, R. C. Heros, M. H. Lavyne, N. T. Zervas, C. N. Nelson

Research output: Contribution to journalArticle

20 Scopus citations


Local cerebral blood flow was measured with the hydrogen clearance technique during intravenous infusion of nitroprusside in monkeys. Concentrations of the drug required to reduce the mean arterial blood pressure by less than 40% resulted in no significant change or only a slight increase in regional cerebral blood flow. Larger doses, however, produced a loss of cerebral autoregulation, thereby inducing a drop in cerebral blood flow. Intracranial pressure rose proportionately to the nitroprusside dose during the infusion.

Original languageEnglish (US)
Pages (from-to)50-53
Number of pages4
Issue number1
StatePublished - Jan 1 1978


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this