Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure.

G. J. Candia, Roberto Heros, M. H. Lavyne, N. T. Zervas, C. N. Nelson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Local cerebral blood flow was measured with the hydrogen clearance technique during intravenous infusion of nitroprusside in monkeys. Concentrations of the drug required to reduce the mean arterial blood pressure by less than 40% resulted in no significant change or only a slight increase in regional cerebral blood flow. Larger doses, however, produced a loss of cerebral autoregulation, thereby inducing a drop in cerebral blood flow. Intracranial pressure rose proportionately to the nitroprusside dose during the infusion.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalNeurosurgery
Volume3
Issue number1
StatePublished - Jul 1 1978
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Intracranial Pressure
Nitroprusside
Blood Pressure
Arterial Pressure
Regional Blood Flow
Intravenous Infusions
Haplorhini
Hydrogen
Homeostasis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Candia, G. J., Heros, R., Lavyne, M. H., Zervas, N. T., & Nelson, C. N. (1978). Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure. Neurosurgery, 3(1), 50-53.

Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure. / Candia, G. J.; Heros, Roberto; Lavyne, M. H.; Zervas, N. T.; Nelson, C. N.

In: Neurosurgery, Vol. 3, No. 1, 01.07.1978, p. 50-53.

Research output: Contribution to journalArticle

Candia, GJ, Heros, R, Lavyne, MH, Zervas, NT & Nelson, CN 1978, 'Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure.', Neurosurgery, vol. 3, no. 1, pp. 50-53.
Candia, G. J. ; Heros, Roberto ; Lavyne, M. H. ; Zervas, N. T. ; Nelson, C. N. / Effect of intravenous sodium nitroprusside on cerebral blood flow and intracranial pressure. In: Neurosurgery. 1978 ; Vol. 3, No. 1. pp. 50-53.
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