Effect of intracerebroventricular administration of β-/Tyr9/-melanotropin-/9-18/ on rotational behavior induced by substantia nigra lesion in rats

L. Vécsei, I. Bollók, G. Telegdy, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

β-/Tyr9/melanotropin-/9-18/ administered intracerebroventricularly /icv./ in doses of 1 μ/rat or 10 μg/rat had no influence on the substantia nigra lesion-induced turning activity of rats, however, it was able to potentiate apomorphine-induced contralateral turning. In a dose of 20 μg/rat /icv./ the peptide alone induced clear contralateral turning. The results suggest that at lower doses the peptide facilitates apomorphine-induced dopamine receptor stimulation, while in a higher dose the peptide alone can stimulate dopamine receptor activity.

Original languageEnglish (US)
Pages (from-to)435-442
Number of pages8
JournalNeuropeptides
Volume3
Issue number6
DOIs
StatePublished - Oct 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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