Effect of intracerebroventricular administration of β-/Tyr9/-melanotropin-/9-18/ on rotational behavior induced by substantia nigra lesion in rats

L. Vécsei, I. Bollók, G. Telegdy, D. H. Coy, Andrew V Schally

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

β-/Tyr9/melanotropin-/9-18/ administered intracerebroventricularly /icv./ in doses of 1 μ/rat or 10 μg/rat had no influence on the substantia nigra lesion-induced turning activity of rats, however, it was able to potentiate apomorphine-induced contralateral turning. In a dose of 20 μg/rat /icv./ the peptide alone induced clear contralateral turning. The results suggest that at lower doses the peptide facilitates apomorphine-induced dopamine receptor stimulation, while in a higher dose the peptide alone can stimulate dopamine receptor activity.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalNeuropeptides
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Melanocyte-Stimulating Hormones
Substantia Nigra
Rats
Apomorphine
Dopamine Receptors
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Effect of intracerebroventricular administration of β-/Tyr9/-melanotropin-/9-18/ on rotational behavior induced by substantia nigra lesion in rats. / Vécsei, L.; Bollók, I.; Telegdy, G.; Coy, D. H.; Schally, Andrew V.

In: Neuropeptides, Vol. 3, No. 6, 01.01.1983, p. 435-442.

Research output: Contribution to journalArticle

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