Effect of internal viral sequences on the utility of retroviral vectors

D. Armentano, S. F. Yu, P. W. Kantoff, T. von Ruden, W. F. Anderson, E. Gilboa

Research output: Contribution to journalArticle

253 Scopus citations

Abstract

Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus.

Original languageEnglish (US)
Pages (from-to)1647-1650
Number of pages4
JournalJournal of virology
Volume61
Issue number5
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Armentano, D., Yu, S. F., Kantoff, P. W., von Ruden, T., Anderson, W. F., & Gilboa, E. (1987). Effect of internal viral sequences on the utility of retroviral vectors. Journal of virology, 61(5), 1647-1650. https://doi.org/10.1128/jvi.61.5.1647-1650.1987