Effect of internal viral sequences on the utility of retroviral vectors

D. Armentano, S. F. Yu, P. W. Kantoff, T. von Ruden, W. F. Anderson, E. Gilboa

Research output: Contribution to journalArticlepeer-review

257 Scopus citations

Abstract

Expression of the human ADA cDNA encoded by the Moloney murine leukemia virus spliced RNA form is enhanced by intron-contained sequences. The presence of sequences corresponding to the viral gag gene in a Moloney murine leukemia virus-based vector results in the generation of 10- to 40-fold higher titers of virus.

Original languageEnglish (US)
Pages (from-to)1647-1650
Number of pages4
JournalJournal of virology
Volume61
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint Dive into the research topics of 'Effect of internal viral sequences on the utility of retroviral vectors'. Together they form a unique fingerprint.

Cite this