Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats

Seth R. Thaller; Michael A. Salzhauer; Adam J. Rubinstein; Alain Thion; Henry Tesluk

doi:10.1097/00001665-199803000-00010

Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats

Seth R. Thaller, Michael A. Salzhauer, Adam J. Rubinstein, Alain Thion, Henry Tesluk

Surgery

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.

Original language	English (US)
Pages (from-to)	138-141
Number of pages	4
Journal	Journal of Craniofacial Surgery
Volume	9
Issue number	2
DOIs	https://doi.org/10.1097/00001665-199803000-00010
State	Published - Mar 1998

Keywords

Critical size calvarial bone defects
Insulin-like growth factor type I

ASJC Scopus subject areas

Surgery

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abstract = "Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.",

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AU - Thaller, Seth R.

AU - Salzhauer, Michael A.

AU - Rubinstein, Adam J.

AU - Thion, Alain

AU - Tesluk, Henry

PY - 1998/3

Y1 - 1998/3

N2 - Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.

AB - Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.

KW - Critical size calvarial bone defects

KW - Insulin-like growth factor type I

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ER -

Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats

Abstract

Keywords

ASJC Scopus subject areas

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