Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats

Seth Thaller, Michael A. Salzhauer, Adam J. Rubinstein, Alain Thion, Henry Tesluk

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalJournal of Craniofacial Surgery
Volume9
Issue number2
StatePublished - Mar 1 1998

Fingerprint

Somatomedins
Insulin-Like Growth Factor I
Bone and Bones
Sprague Dawley Rats
Collagen
Wounds and Injuries

Keywords

  • Critical size calvarial bone defects
  • Insulin-like growth factor type I

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats. / Thaller, Seth; Salzhauer, Michael A.; Rubinstein, Adam J.; Thion, Alain; Tesluk, Henry.

In: Journal of Craniofacial Surgery, Vol. 9, No. 2, 01.03.1998, p. 138-141.

Research output: Contribution to journalArticle

Thaller, Seth ; Salzhauer, Michael A. ; Rubinstein, Adam J. ; Thion, Alain ; Tesluk, Henry. / Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats. In: Journal of Craniofacial Surgery. 1998 ; Vol. 9, No. 2. pp. 138-141.
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