Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats

Seth R. Thaller, Michael A. Salzhauer, Adam J. Rubinstein, Alain Thion, Henry Tesluk

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Irradiated wounds are characterized by a slow healing process. Insulin-like growth factor-1 (IGF-1), a somatomedin C, has been shown in previous studies to stimulate collagen synthesis and bony repair. The purpose of this investigation is to evaluate the potential beneficial effects of recombinant IGF-1 in the healing of critical size calvarial defects in previously irradiated adult male Sprague-Dawley Rats.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalJournal of Craniofacial Surgery
Volume9
Issue number2
DOIs
StatePublished - Mar 1998

Keywords

  • Critical size calvarial bone defects
  • Insulin-like growth factor type I

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Effect of insulin-like growth factor type I on critical size calvarial bone defects in irradiated rats'. Together they form a unique fingerprint.

  • Cite this