Effect of insulin-like growth factor-1 on zygomatic arch bone regeneration

A preliminary histological and histometric study

Seth Thaller, J. Hoyt, H. Tesluk, R. Holmes

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A number of physicians have attempted to pharmacologically manipulate the healing of bony fractures with a variety of agents such as growth hormone, thyroxine, chondroitin sulfate, and parathyroid hormone. Thus far, results from these experiments have been inconclusive. Previous research dealing with insulin-like growth factors has centered on cultures of osteoblast-like cells and has demonstrated a stimulatory effect on bone collagen synthesis, which may in fact play a critical role in the process of bone formation itself. The purpose of this investigation was to examine the effects of a genetically engineered growth factor, insulin growth factor type I, on midfacial fracture healing. In 24 adult male Sprague-Dawley rats, a standardized defect was created within the midportion of each zygomatic arch. One-half were treated with insulin growth factor type I administered with an osmotic infusion pump and the other half served as control subjects. At 2, 4, 8, and 12 weeks, animals from each group were killed and specimens of the defect obtained. Data were collected from radiographs and histological studies to compare the extent of bony repair. From this study, it appears that insulin growth factor type I could exert a potentiating effect on the repair of midfacial bone defects.

Original languageEnglish
Pages (from-to)421-428
Number of pages8
JournalAnnals of Plastic Surgery
Volume31
Issue number5
DOIs
StatePublished - Nov 23 1993
Externally publishedYes

Fingerprint

Zygoma
Bone Regeneration
Somatomedins
Intercellular Signaling Peptides and Proteins
Fracture Healing
Insulin
Bone and Bones
Infusion Pumps
Chondroitin Sulfates
Parathyroid Hormone
Osteoblasts
Osteogenesis
Growth Hormone
Sprague Dawley Rats
Collagen
Physicians
Research

ASJC Scopus subject areas

  • Surgery

Cite this

Effect of insulin-like growth factor-1 on zygomatic arch bone regeneration : A preliminary histological and histometric study. / Thaller, Seth; Hoyt, J.; Tesluk, H.; Holmes, R.

In: Annals of Plastic Surgery, Vol. 31, No. 5, 23.11.1993, p. 421-428.

Research output: Contribution to journalArticle

@article{594451d0a16f4d929ec61f99e4243b27,
title = "Effect of insulin-like growth factor-1 on zygomatic arch bone regeneration: A preliminary histological and histometric study",
abstract = "A number of physicians have attempted to pharmacologically manipulate the healing of bony fractures with a variety of agents such as growth hormone, thyroxine, chondroitin sulfate, and parathyroid hormone. Thus far, results from these experiments have been inconclusive. Previous research dealing with insulin-like growth factors has centered on cultures of osteoblast-like cells and has demonstrated a stimulatory effect on bone collagen synthesis, which may in fact play a critical role in the process of bone formation itself. The purpose of this investigation was to examine the effects of a genetically engineered growth factor, insulin growth factor type I, on midfacial fracture healing. In 24 adult male Sprague-Dawley rats, a standardized defect was created within the midportion of each zygomatic arch. One-half were treated with insulin growth factor type I administered with an osmotic infusion pump and the other half served as control subjects. At 2, 4, 8, and 12 weeks, animals from each group were killed and specimens of the defect obtained. Data were collected from radiographs and histological studies to compare the extent of bony repair. From this study, it appears that insulin growth factor type I could exert a potentiating effect on the repair of midfacial bone defects.",
author = "Seth Thaller and J. Hoyt and H. Tesluk and R. Holmes",
year = "1993",
month = "11",
day = "23",
doi = "10.1097/00000637-199311000-00006",
language = "English",
volume = "31",
pages = "421--428",
journal = "Annals of Plastic Surgery",
issn = "0148-7043",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Effect of insulin-like growth factor-1 on zygomatic arch bone regeneration

T2 - A preliminary histological and histometric study

AU - Thaller, Seth

AU - Hoyt, J.

AU - Tesluk, H.

AU - Holmes, R.

PY - 1993/11/23

Y1 - 1993/11/23

N2 - A number of physicians have attempted to pharmacologically manipulate the healing of bony fractures with a variety of agents such as growth hormone, thyroxine, chondroitin sulfate, and parathyroid hormone. Thus far, results from these experiments have been inconclusive. Previous research dealing with insulin-like growth factors has centered on cultures of osteoblast-like cells and has demonstrated a stimulatory effect on bone collagen synthesis, which may in fact play a critical role in the process of bone formation itself. The purpose of this investigation was to examine the effects of a genetically engineered growth factor, insulin growth factor type I, on midfacial fracture healing. In 24 adult male Sprague-Dawley rats, a standardized defect was created within the midportion of each zygomatic arch. One-half were treated with insulin growth factor type I administered with an osmotic infusion pump and the other half served as control subjects. At 2, 4, 8, and 12 weeks, animals from each group were killed and specimens of the defect obtained. Data were collected from radiographs and histological studies to compare the extent of bony repair. From this study, it appears that insulin growth factor type I could exert a potentiating effect on the repair of midfacial bone defects.

AB - A number of physicians have attempted to pharmacologically manipulate the healing of bony fractures with a variety of agents such as growth hormone, thyroxine, chondroitin sulfate, and parathyroid hormone. Thus far, results from these experiments have been inconclusive. Previous research dealing with insulin-like growth factors has centered on cultures of osteoblast-like cells and has demonstrated a stimulatory effect on bone collagen synthesis, which may in fact play a critical role in the process of bone formation itself. The purpose of this investigation was to examine the effects of a genetically engineered growth factor, insulin growth factor type I, on midfacial fracture healing. In 24 adult male Sprague-Dawley rats, a standardized defect was created within the midportion of each zygomatic arch. One-half were treated with insulin growth factor type I administered with an osmotic infusion pump and the other half served as control subjects. At 2, 4, 8, and 12 weeks, animals from each group were killed and specimens of the defect obtained. Data were collected from radiographs and histological studies to compare the extent of bony repair. From this study, it appears that insulin growth factor type I could exert a potentiating effect on the repair of midfacial bone defects.

UR - http://www.scopus.com/inward/record.url?scp=0027448823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027448823&partnerID=8YFLogxK

U2 - 10.1097/00000637-199311000-00006

DO - 10.1097/00000637-199311000-00006

M3 - Article

VL - 31

SP - 421

EP - 428

JO - Annals of Plastic Surgery

JF - Annals of Plastic Surgery

SN - 0148-7043

IS - 5

ER -