Effect of injury on nerve growth factor uptake by sensory ganglia

T. Khan, B. Green, R. J. Perez‐Polo

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The level of the nerve growth factor protein, NGF, in vivo has a profound influence on axonal sprouting by sensory neurons of vertebrate dorsal root ganglia. There is evidence also that NGF may play similar roles in cholinergic central structures in brain. In both instances, retrograde transport of NGF has been demonstrated. Here we examined uptake of NGF by DRG neurons in response to contusion injury of the spinal cord. Under these conditions there was uptake and transport of NGF into large DRG neurons via central processes but no uptake by non-DRG central neurons. Thus, any effect of NGF on spinal neurons or their processes would be secondary to the direct effects of NGF on DRG neurons.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalJournal of Neuroscience Research
Volume18
Issue number4
DOIs
StatePublished - 1987

Keywords

  • axonal sprouting
  • cholinergic central structures
  • contusion injury of spinal cord
  • dorsal root ganglia
  • nerve growth factor protein
  • retrograde transport

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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