Effect of hyperventilation on airway mucosal blood flow in normal subjects

Helen H. Kim, Charles Lemerre, Cuneyt M. Demirozu, Alejanoro D. Chediak, Adam Wanner

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The purpose of this study was to determine the effect of hyperventilation (40 L/min) with room air (25° C; 70% relative humidity) and frigid air (-10° C; 0% relative humidity) on airway mucosal blood flow (Q̇aw) in normal subjects (n = 7; 26 to 54 yr of age). Q̇aw was measured with the dimethyl ether uptake technique, which reflects blood flow in the mucosa of large airways corresponding to a 50-ml anatomic dead space segment extending distally from the trachea. Mean (± SE) baseline Q̇aw during quiet (room air) breathing was 6.6 ± 0.6 ml/min (range, 3.9 to 10.9). Q̇aw failed to change significantly during and after eucapnic hyperventilation with room air (thermal stress, 224 cal/min). In contrast, eucapnic hyperventilation with frigid air (thermal stress, 720 cal/min) increased Q̇aw in every subject, with the peak value occurring either during or over a 30-min period after hyperventilation; by 60 min, Q̇aw had returned toward baseline. The mean maximal Q̇aw was 310 ± 49% of baseline (p < 0.05). Neither type of hyperventilation had an effect on airway resistance. We conclude that in normal subjects, Q̇aw increases during and/or after eucapnic hyperventilation with frigid air, and that this response is related to the magnitude of the thermal stress rather than to the level of ventilation.

Original languageEnglish (US)
Pages (from-to)1563-1566
Number of pages4
JournalAmerican journal of respiratory and critical care medicine
Issue number5
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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