Abstract
The purpose of this study was to determine the effect of hyperventilation (40 L/min) with room air (25° C; 70% relative humidity) and frigid air (-10° C; 0% relative humidity) on airway mucosal blood flow (Q̇aw) in normal subjects (n = 7; 26 to 54 yr of age). Q̇aw was measured with the dimethyl ether uptake technique, which reflects blood flow in the mucosa of large airways corresponding to a 50-ml anatomic dead space segment extending distally from the trachea. Mean (± SE) baseline Q̇aw during quiet (room air) breathing was 6.6 ± 0.6 ml/min (range, 3.9 to 10.9). Q̇aw failed to change significantly during and after eucapnic hyperventilation with room air (thermal stress, 224 cal/min). In contrast, eucapnic hyperventilation with frigid air (thermal stress, 720 cal/min) increased Q̇aw in every subject, with the peak value occurring either during or over a 30-min period after hyperventilation; by 60 min, Q̇aw had returned toward baseline. The mean maximal Q̇aw was 310 ± 49% of baseline (p < 0.05). Neither type of hyperventilation had an effect on airway resistance. We conclude that in normal subjects, Q̇aw increases during and/or after eucapnic hyperventilation with frigid air, and that this response is related to the magnitude of the thermal stress rather than to the level of ventilation.
| Original language | English |
|---|---|
| Pages (from-to) | 1563-1566 |
| Number of pages | 4 |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 154 |
| Issue number | 5 |
| State | Published - Dec 2 1996 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Effect of hyperventilation on airway mucosal blood flow in normal subjects. / Kim, Helen H.; Lemerre, Charles; Demirozu, Cuneyt M.; Chediak, Alejandro D.; Wanner, Adam.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 154, No. 5, 02.12.1996, p. 1563-1566.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hyperventilation on airway mucosal blood flow in normal subjects
AU - Kim, Helen H.
AU - Lemerre, Charles
AU - Demirozu, Cuneyt M.
AU - Chediak, Alejandro D.
AU - Wanner, Adam
PY - 1996/12/2
Y1 - 1996/12/2
N2 - The purpose of this study was to determine the effect of hyperventilation (40 L/min) with room air (25° C; 70% relative humidity) and frigid air (-10° C; 0% relative humidity) on airway mucosal blood flow (Q̇aw) in normal subjects (n = 7; 26 to 54 yr of age). Q̇aw was measured with the dimethyl ether uptake technique, which reflects blood flow in the mucosa of large airways corresponding to a 50-ml anatomic dead space segment extending distally from the trachea. Mean (± SE) baseline Q̇aw during quiet (room air) breathing was 6.6 ± 0.6 ml/min (range, 3.9 to 10.9). Q̇aw failed to change significantly during and after eucapnic hyperventilation with room air (thermal stress, 224 cal/min). In contrast, eucapnic hyperventilation with frigid air (thermal stress, 720 cal/min) increased Q̇aw in every subject, with the peak value occurring either during or over a 30-min period after hyperventilation; by 60 min, Q̇aw had returned toward baseline. The mean maximal Q̇aw was 310 ± 49% of baseline (p < 0.05). Neither type of hyperventilation had an effect on airway resistance. We conclude that in normal subjects, Q̇aw increases during and/or after eucapnic hyperventilation with frigid air, and that this response is related to the magnitude of the thermal stress rather than to the level of ventilation.
AB - The purpose of this study was to determine the effect of hyperventilation (40 L/min) with room air (25° C; 70% relative humidity) and frigid air (-10° C; 0% relative humidity) on airway mucosal blood flow (Q̇aw) in normal subjects (n = 7; 26 to 54 yr of age). Q̇aw was measured with the dimethyl ether uptake technique, which reflects blood flow in the mucosa of large airways corresponding to a 50-ml anatomic dead space segment extending distally from the trachea. Mean (± SE) baseline Q̇aw during quiet (room air) breathing was 6.6 ± 0.6 ml/min (range, 3.9 to 10.9). Q̇aw failed to change significantly during and after eucapnic hyperventilation with room air (thermal stress, 224 cal/min). In contrast, eucapnic hyperventilation with frigid air (thermal stress, 720 cal/min) increased Q̇aw in every subject, with the peak value occurring either during or over a 30-min period after hyperventilation; by 60 min, Q̇aw had returned toward baseline. The mean maximal Q̇aw was 310 ± 49% of baseline (p < 0.05). Neither type of hyperventilation had an effect on airway resistance. We conclude that in normal subjects, Q̇aw increases during and/or after eucapnic hyperventilation with frigid air, and that this response is related to the magnitude of the thermal stress rather than to the level of ventilation.
UR - http://www.scopus.com/inward/record.url?scp=0029849327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029849327&partnerID=8YFLogxK
M3 - Article
C2 - 8912781
AN - SCOPUS:0029849327
VL - 154
SP - 1563
EP - 1566
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 5
ER -