Effect of hyperkalemia on insulin secretion

R. Martinez, B. Rietberg, J. Skyler, J. R. Oster, G. O. Perez

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p<0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
Issue number3
StatePublished - Mar 1 1991


  • glucose
  • hyperkalemia
  • Insulin
  • portal vein
  • potassium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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