Effect of hyperkalemia on insulin secretion

R. Martinez, B. Rietberg, Jay S Skyler, J. R. Oster, G. O. Perez

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p<0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalExperientia
Volume47
Issue number3
DOIs
StatePublished - Mar 1 1991

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Hyperkalemia
Insulin
Potassium
Plasmas
Dogs

Keywords

  • glucose
  • hyperkalemia
  • Insulin
  • portal vein
  • potassium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Martinez, R., Rietberg, B., Skyler, J. S., Oster, J. R., & Perez, G. O. (1991). Effect of hyperkalemia on insulin secretion. Experientia, 47(3), 270-272. https://doi.org/10.1007/BF01958157

Effect of hyperkalemia on insulin secretion. / Martinez, R.; Rietberg, B.; Skyler, Jay S; Oster, J. R.; Perez, G. O.

In: Experientia, Vol. 47, No. 3, 01.03.1991, p. 270-272.

Research output: Contribution to journalArticle

Martinez, R, Rietberg, B, Skyler, JS, Oster, JR & Perez, GO 1991, 'Effect of hyperkalemia on insulin secretion', Experientia, vol. 47, no. 3, pp. 270-272. https://doi.org/10.1007/BF01958157
Martinez R, Rietberg B, Skyler JS, Oster JR, Perez GO. Effect of hyperkalemia on insulin secretion. Experientia. 1991 Mar 1;47(3):270-272. https://doi.org/10.1007/BF01958157
Martinez, R. ; Rietberg, B. ; Skyler, Jay S ; Oster, J. R. ; Perez, G. O. / Effect of hyperkalemia on insulin secretion. In: Experientia. 1991 ; Vol. 47, No. 3. pp. 270-272.
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