Effect of hyperkalemia on insulin secretion

R. Martinez, B. Rietberg, J. Skyler, J. R. Oster, G. O. Perez

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68±0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p<0.05). We conclude that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.

Original languageEnglish (US)
Pages (from-to)270-272
Number of pages3
JournalExperientia
Volume47
Issue number3
DOIs
StatePublished - Mar 1 1991

Keywords

  • glucose
  • hyperkalemia
  • Insulin
  • portal vein
  • potassium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Effect of hyperkalemia on insulin secretion'. Together they form a unique fingerprint.

Cite this