Effect of hydroxyurea on 2′,3′-dideoxycytidine activation

Ram P. Agarwal, Jun He

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effect of hydroxyurea (HU) on cell growth, cell cycle progression, and the intracellular accumulation of 2',3'0-dideoxycytidine (ddC) and ddCTP formation was examined. Twenty-four-hour exposure of H9 cells (human lymphocytic cell line) to 500 μM HU significantly increased the cells in the G1 phase and inhibited cell growth to 33.3 ± 10.6% of control. The total intracellular ddC and ddCTP accumulation in HU-treated cells increased to 232.3% and 310% of control, respectively.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalBiochemical and biophysical research communications
Volume205
Issue number1
DOIs
StatePublished - Nov 30 1994

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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