Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure

Michal Toborek; Tomasz Wasik; Marian Drózdz; Mariusz Klin; Krystyna Magner-Wróbel; Ewa Kopieczna-Grzebieniak

doi:10.1016/0026-0495(92)90014-2

Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure

Michal Toborek, Tomasz Wasik, Marian Drózdz, Mariusz Klin, Krystyna Magner-Wróbel, Ewa Kopieczna-Grzebieniak

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.

Original language	English (US)
Pages (from-to)	1229-1232
Number of pages	4
Journal	Metabolism
Volume	41
Issue number	11
DOIs	https://doi.org/10.1016/0026-0495(92)90014-2
State	Published - Nov 1992
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/0026-0495(92)90014-2

Fingerprint Dive into the research topics of 'Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure'. Together they form a unique fingerprint.

Cite this

@article{ae26b3324065425e876ad9ee2e71eab6,

title = "Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure",

abstract = "Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.",

author = "Michal Toborek and Tomasz Wasik and Marian Dr{\'o}zdz and Mariusz Klin and Krystyna Magner-Wr{\'o}bel and Ewa Kopieczna-Grzebieniak",

year = "1992",

month = nov,

doi = "10.1016/0026-0495(92)90014-2",

language = "English (US)",

volume = "41",

pages = "1229--1232",

journal = "Metabolism: Clinical and Experimental",

issn = "0026-0495",

publisher = "W.B. Saunders Ltd",

number = "11",

}

TY - JOUR

T1 - Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure

AU - Toborek, Michal

AU - Wasik, Tomasz

AU - Drózdz, Marian

AU - Klin, Mariusz

AU - Magner-Wróbel, Krystyna

AU - Kopieczna-Grzebieniak, Ewa

PY - 1992/11

Y1 - 1992/11

N2 - Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.

AB - Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.

UR - http://www.scopus.com/inward/record.url?scp=0026485071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026485071&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(92)90014-2

DO - 10.1016/0026-0495(92)90014-2

M3 - Article

C2 - 1435296

AN - SCOPUS:0026485071

VL - 41

SP - 1229

EP - 1232

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 11

ER -