Abstract
Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 1229-1232 |
| Number of pages | 4 |
| Journal | Metabolism |
| Volume | 41 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. / Toborek, Michal J; Wasik, Tomasz; Drózdz, Marian; Klin, Mariusz; Magner-Wróbel, Krystyna; Kopieczna-Grzebieniak, Ewa.
In: Metabolism, Vol. 41, No. 11, 01.01.1992, p. 1229-1232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure
AU - Toborek, Michal J
AU - Wasik, Tomasz
AU - Drózdz, Marian
AU - Klin, Mariusz
AU - Magner-Wróbel, Krystyna
AU - Kopieczna-Grzebieniak, Ewa
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.
AB - Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.
UR - http://www.scopus.com/inward/record.url?scp=0026485071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026485071&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(92)90014-2
DO - 10.1016/0026-0495(92)90014-2
M3 - Article
C2 - 1435296
AN - SCOPUS:0026485071
VL - 41
SP - 1229
EP - 1232
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 11
ER -