Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure

Michal Toborek, Tomasz Wasik, Marian Drózdz, Mariusz Klin, Krystyna Magner-Wróbel, Ewa Kopieczna-Grzebieniak

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163 Scopus citations

Abstract

Plasma lipid peroxidation, activity of erythrocyte superoxide dismutase (SOD) and catalase, and serum antioxidant activity (AOA) in uremic patients were examined before and after hemodialysis. An increased level of lipid peroxidation, a decreased serum AOA level, and elevated SOD and normal catalase activity before hemodialysis were observed in uremic patients compared with controls. Hemodialysis was found to produce increased lipid peroxidation, a simultaneous decrease of SOD activity, and lack of any changes in serum AOA and erythrocyte catalase. It is suggested that intensification of lipid peroxidation during hemodialysis could account for accelerated progress of atherosclerosis in patients with renal insufficiency.

Original languageEnglish (US)
Pages (from-to)1229-1232
Number of pages4
JournalMetabolism
Volume41
Issue number11
DOIs
StatePublished - Nov 1992
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Toborek, M., Wasik, T., Drózdz, M., Klin, M., Magner-Wróbel, K., & Kopieczna-Grzebieniak, E. (1992). Effect of hemodialysis on lipid peroxidation and antioxidant system in patients with chronic renal failure. Metabolism, 41(11), 1229-1232. https://doi.org/10.1016/0026-0495(92)90014-2