Effect of graded increases in parasympathetic tone on heart rate variability

Jeffrey Goldberger, You Ho Kim, Mirza W. Ahmed, Alan H. Kadish

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Introduction: Time- and frequency-domain measurements of heart rate variability have been used as indices of parasympathetic tone. However, studies of the effect of parasympathetic stimulation on these indices in humans have yielded conflicting results. Methods and Results: This study evaluated the effects of parasympathetic stimulation on heart rate variability. Twelve normal subjects (7 males, 5 females; age 24.8 ± 3.4 years) were evaluated in the Clinical Research Center. Five-minute ECG recordings were obtained at baseline and during graded phenylephrine infusions (0.3 and 0.6 μg/kg per min). Recordings were made during spontaneous respiration and when breathing was timed with a metronome at 15 cycles/min. Heart rate variability analysis was performed using standard time- and frequency-domain parameters. Graded phenylephrine infusion resulted in a progressive increase in blood pressure and RR interval but no consistent changes in heart rate variability for the group. The results during normal versus metronome breathing were similar. Stepwise linear regression analysis revealed that the phenylephrine-induced changes in heart rate variability were inversely correlated with the baseline heart rate variability and not related to the baseline RR interval or the phenylephrine-induced change in RR interval. Conclusion: These findings suggest that the respiratory variation in 'parasympathetic effect' typically observed at the sinus node can be either increased or decreased by parasympathetic stimulation, depending on the initial level of parasympathetic tone and the intensity of stimulation. This resolves the previously conflicting data. Thus, evaluation of parasympathetic tone using heart rate variability techniques should be cautiously undertaken.

Original languageEnglish (US)
Pages (from-to)594-602
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Volume7
Issue number7
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Heart Rate
Phenylephrine
Respiration
Sinoatrial Node
Linear Models
Electrocardiography
Regression Analysis
Blood Pressure
Research

Keywords

  • autonomic
  • heart rate
  • metronome
  • phenylephrine
  • respiration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Effect of graded increases in parasympathetic tone on heart rate variability. / Goldberger, Jeffrey; Kim, You Ho; Ahmed, Mirza W.; Kadish, Alan H.

In: Journal of Cardiovascular Electrophysiology, Vol. 7, No. 7, 01.01.1996, p. 594-602.

Research output: Contribution to journalArticle

Goldberger, Jeffrey ; Kim, You Ho ; Ahmed, Mirza W. ; Kadish, Alan H. / Effect of graded increases in parasympathetic tone on heart rate variability. In: Journal of Cardiovascular Electrophysiology. 1996 ; Vol. 7, No. 7. pp. 594-602.
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