Abstract
This chapter discusses pancreatic lesions that occur more frequently in men or women, evaluates the mechanisms by which they occur, and reviews their clinical course and therapy. Sex steroid hormones (SSH) including estrogens, progestagens, and androgens are responsible for sexual differentiation, and their major target organs are the mammary glands, urogenital tract, bone, cardiovascular and central nervous systems. Epidemiologic, clinical, and biochemical findings have shown the relationship between gender and prevalence of some tumors of the pancreas, the effect of pregnancy on insulin and glucose metabolism, and the identification of SSH receptors in pancreatic tissue. The study of gender-specific pancreatic lesions provides clues regarding their origin, development, tumoral behavior, prognosis, and more specific hormonal therapy. The varying effects of sex steroid hormones (SSH) in development and growth of pancreatic neoplasms may be related to the mechanism affecting carcinogenesis, and may be multifactorial and/or different for each hormone. Clinical trials designed to evaluate the response of cancer of the pancreas to hormonal therapy have been inconclusive.
| Original language | English |
|---|---|
| Title of host publication | Principles of Gender-Specific Medicine |
| Publisher | Elsevier Inc. |
| Pages | 454-462 |
| Number of pages | 9 |
| Volume | 1 |
| ISBN (Print) | 9780124409057 |
| DOIs | |
| State | Published - Dec 1 2004 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Effect of Gender on Pancreatic Disease. / O'Loughlin, Colm J.; Karnam, Umaprasanna S.; Barkin, Jamie S.
Principles of Gender-Specific Medicine. Vol. 1 Elsevier Inc., 2004. p. 454-462.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Effect of Gender on Pancreatic Disease
AU - O'Loughlin, Colm J.
AU - Karnam, Umaprasanna S.
AU - Barkin, Jamie S
PY - 2004/12/1
Y1 - 2004/12/1
N2 - This chapter discusses pancreatic lesions that occur more frequently in men or women, evaluates the mechanisms by which they occur, and reviews their clinical course and therapy. Sex steroid hormones (SSH) including estrogens, progestagens, and androgens are responsible for sexual differentiation, and their major target organs are the mammary glands, urogenital tract, bone, cardiovascular and central nervous systems. Epidemiologic, clinical, and biochemical findings have shown the relationship between gender and prevalence of some tumors of the pancreas, the effect of pregnancy on insulin and glucose metabolism, and the identification of SSH receptors in pancreatic tissue. The study of gender-specific pancreatic lesions provides clues regarding their origin, development, tumoral behavior, prognosis, and more specific hormonal therapy. The varying effects of sex steroid hormones (SSH) in development and growth of pancreatic neoplasms may be related to the mechanism affecting carcinogenesis, and may be multifactorial and/or different for each hormone. Clinical trials designed to evaluate the response of cancer of the pancreas to hormonal therapy have been inconclusive.
AB - This chapter discusses pancreatic lesions that occur more frequently in men or women, evaluates the mechanisms by which they occur, and reviews their clinical course and therapy. Sex steroid hormones (SSH) including estrogens, progestagens, and androgens are responsible for sexual differentiation, and their major target organs are the mammary glands, urogenital tract, bone, cardiovascular and central nervous systems. Epidemiologic, clinical, and biochemical findings have shown the relationship between gender and prevalence of some tumors of the pancreas, the effect of pregnancy on insulin and glucose metabolism, and the identification of SSH receptors in pancreatic tissue. The study of gender-specific pancreatic lesions provides clues regarding their origin, development, tumoral behavior, prognosis, and more specific hormonal therapy. The varying effects of sex steroid hormones (SSH) in development and growth of pancreatic neoplasms may be related to the mechanism affecting carcinogenesis, and may be multifactorial and/or different for each hormone. Clinical trials designed to evaluate the response of cancer of the pancreas to hormonal therapy have been inconclusive.
UR - http://www.scopus.com/inward/record.url?scp=84902054953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902054953&partnerID=8YFLogxK
U2 - 10.1016/B978-012440905-7/50311-X
DO - 10.1016/B978-012440905-7/50311-X
M3 - Chapter
AN - SCOPUS:84902054953
SN - 9780124409057
VL - 1
SP - 454
EP - 462
BT - Principles of Gender-Specific Medicine
PB - Elsevier Inc.
ER -