Effect of foscarnet therapy on human immunodeficiency virus p24 antigen levels in aids patients with cytomegalovirus retinitis

Mohan M. Reddy, Michael H. Grieco, George F. McKinley, Dennis M. Causey, M. van der Horst Charles, David M. Parenti, Thomas M. Hooton, Roger B. Davis, Mark A. Jacobson

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Abstract

Circulating human immunodeficiency virus (HIV) p24 antigen levels were measured in 22 AIDS patients who had detectable serum antigen at baseline after induction and maintenance therapy of foscarnet for cytomegalovirus retinitis in phase I/II multicenter trials. The HIV p24 antigen levels decreased from a baseline value of 199 ± 236 (mean ± SD) and 140 pg/mL (median) to 106 ± 218 and 28 pg/mL after 14 days of foscarnet induction therapy (60 mg/kg every 8 h). During chronic foscarnet maintenance, there was a sustained decrease in mean HIV p24 antigen levels below pre-foscarnet therapy baseline concentrations for a median of 16 weeks after foscarnet induction. These results provide evidence for a sustained clinical antiretroviral effect of chronic foscarnet maintenance therapy, consistent with a recent report that foscarnet-treated AIDS patients live longer than ganciclovir-treated patients.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalJournal of Infectious Diseases
Volume166
Issue number3
DOIs
StatePublished - Sep 1992

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Reddy, M. M., Grieco, M. H., McKinley, G. F., Causey, D. M., van der Horst Charles, M., Parenti, D. M., Hooton, T. M., Davis, R. B., & Jacobson, M. A. (1992). Effect of foscarnet therapy on human immunodeficiency virus p24 antigen levels in aids patients with cytomegalovirus retinitis. Journal of Infectious Diseases, 166(3), 607-610. https://doi.org/10.1093/infdis/166.3.607