Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia

S. Kolluri, Roberto Heros, E. T. Hedley-Whyte, J. P. Vonsattel, D. Miller, N. T. Zervas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100% oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which, in turn, was related to the degree of ischemia during the time of occlusion.

Original languageEnglish
Pages (from-to)976-980
Number of pages5
JournalStroke
Volume17
Issue number5
StatePublished - Dec 19 1986
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Brain Ischemia
Oxygen
Ischemia
Mortality
Middle Cerebral Artery Infarction
Platinum
Intravenous Infusions
Infarction
Reperfusion
Hydrogen
Electrodes
Cats
fluosol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Kolluri, S., Heros, R., Hedley-Whyte, E. T., Vonsattel, J. P., Miller, D., & Zervas, N. T. (1986). Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia. Stroke, 17(5), 976-980.

Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia. / Kolluri, S.; Heros, Roberto; Hedley-Whyte, E. T.; Vonsattel, J. P.; Miller, D.; Zervas, N. T.

In: Stroke, Vol. 17, No. 5, 19.12.1986, p. 976-980.

Research output: Contribution to journalArticle

Kolluri, S, Heros, R, Hedley-Whyte, ET, Vonsattel, JP, Miller, D & Zervas, NT 1986, 'Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia', Stroke, vol. 17, no. 5, pp. 976-980.
Kolluri, S. ; Heros, Roberto ; Hedley-Whyte, E. T. ; Vonsattel, J. P. ; Miller, D. ; Zervas, N. T. / Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia. In: Stroke. 1986 ; Vol. 17, No. 5. pp. 976-980.
@article{d11d95816d3b4c9e9f5a6e6e0bebed8e,
title = "Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia",
abstract = "Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100{\%} O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100{\%} oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which, in turn, was related to the degree of ischemia during the time of occlusion.",
author = "S. Kolluri and Roberto Heros and Hedley-Whyte, {E. T.} and Vonsattel, {J. P.} and D. Miller and Zervas, {N. T.}",
year = "1986",
month = "12",
day = "19",
language = "English",
volume = "17",
pages = "976--980",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Effect of fluosol on oxygen availability, regional cerebral blood flow, and infarct size in a model of temporary focal cerebral ischemia

AU - Kolluri, S.

AU - Heros, Roberto

AU - Hedley-Whyte, E. T.

AU - Vonsattel, J. P.

AU - Miller, D.

AU - Zervas, N. T.

PY - 1986/12/19

Y1 - 1986/12/19

N2 - Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100% oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which, in turn, was related to the degree of ischemia during the time of occlusion.

AB - Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100% oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which, in turn, was related to the degree of ischemia during the time of occlusion.

UR - http://www.scopus.com/inward/record.url?scp=0022507961&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022507961&partnerID=8YFLogxK

M3 - Article

C2 - 3764970

AN - SCOPUS:0022507961

VL - 17

SP - 976

EP - 980

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 5

ER -