Effect of Estradiol on the Response to LH-RH in Male Rats at Different Times After Castration

Luciano Debeljuk, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The effects of pretreatment with estradiol benzoate on the pituitary release of LH and FSH in response to LH RH were investigated in male rats at various time intervals after castration. In oil treated control rats, LH RH brought about a significant increase in serum LH at all the periods after castration. One day after castration, pretreatment with estradiol significantly inhibited the response to LH RH, as observed in normal male rats. One week after castration estradiol induced a greater response to LH RH than observed in oil treated control rats, although the difference was not significant. One and two months after castration, estradiol significantly increased the response to LH RH.

Original languageEnglish (US)
Pages (from-to)1164-1167
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume143
Issue number4
DOIs
StatePublished - Sep 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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