TY - JOUR
T1 - Effect of Estradiol on the Response to LH-RH in Male Rats at Different Times After Castration
AU - Debeljuk, Luciano
AU - Arimura, Akira
AU - Schally, Andrew V.
N1 - Funding Information:
Supported in part by U.S. Public Health Service Research Grants AM-09094, AM-07467, the Population Council, New York, and Veterans Administration.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1973/9
Y1 - 1973/9
N2 - The effects of pretreatment with estradiol benzoate on the pituitary release of LH and FSH in response to LH RH were investigated in male rats at various time intervals after castration. In oil treated control rats, LH RH brought about a significant increase in serum LH at all the periods after castration. One day after castration, pretreatment with estradiol significantly inhibited the response to LH RH, as observed in normal male rats. One week after castration estradiol induced a greater response to LH RH than observed in oil treated control rats, although the difference was not significant. One and two months after castration, estradiol significantly increased the response to LH RH.
AB - The effects of pretreatment with estradiol benzoate on the pituitary release of LH and FSH in response to LH RH were investigated in male rats at various time intervals after castration. In oil treated control rats, LH RH brought about a significant increase in serum LH at all the periods after castration. One day after castration, pretreatment with estradiol significantly inhibited the response to LH RH, as observed in normal male rats. One week after castration estradiol induced a greater response to LH RH than observed in oil treated control rats, although the difference was not significant. One and two months after castration, estradiol significantly increased the response to LH RH.
UR - http://www.scopus.com/inward/record.url?scp=0015868752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015868752&partnerID=8YFLogxK
U2 - 10.3181/00379727-143-37492
DO - 10.3181/00379727-143-37492
M3 - Article
C2 - 4743696
AN - SCOPUS:0015868752
VL - 143
SP - 1164
EP - 1167
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 4
ER -