Effect of epigallocatechin-3-gallate on graft-versus-host disease

Jaebok Choi, Matthew L. Cooper, Edward D. Ziga, Julie Ritchey, John F. DiPersio

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is often complicated by alloreactive donor T-cell-mediated graft-versus-host disease (GvHD). The major polyphenol of green tea, epigallocatechin-3-gallate (EGCG), is an inhibitor of both DNA methyltransferase 1 (DNMT1) and signal transducer and activator of transcription 1 (STAT1), which are essential for induction of GvHD. Thus, in this report, we examine if in vivo administration of EGCG mitigates GvHD in several different animal models. While we concede that refinement of EGCG treatment might result in GvHD prevention, our results suggest that EGCG treatment might not be an effective therapy against GvHD in the clinic.

Original languageEnglish (US)
Pages (from-to)1163-1166
Number of pages4
JournalCell transplantation
Volume23
Issue number9
DOIs
StatePublished - Jan 1 2014

Keywords

  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT)
  • DNA methyltransferase 1 (DNMT1)
  • Epigallocatechin-3-gallate (EGCG)
  • Graft-versus-host disease (GvHD)
  • Interferon-γ receptor signaling
  • Signal transducer and activator of transcription 1 (STAT1)

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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