In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.
|Original language||English (US)|
|Number of pages||7|
|Journal||Annals of the New York Academy of Sciences|
|State||Published - Dec 1988|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science