Effect of enzyme deactivation on substrate conversion in fixed- and fluid-bed reactors. Influence of enzyme microheterogeneity

Arun Malhotra, A. Sadana

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume542
StatePublished - Dec 1 1989
Externally publishedYes

Fingerprint

Fluids
Substrates
Enzymes
Immobilization
Substrate
Physical

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{4073af142ba44354bc7664907b7f093a,
title = "Effect of enzyme deactivation on substrate conversion in fixed- and fluid-bed reactors. Influence of enzyme microheterogeneity",
abstract = "In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.",
author = "Arun Malhotra and A. Sadana",
year = "1989",
month = "12",
day = "1",
language = "English",
volume = "542",
pages = "312--318",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Effect of enzyme deactivation on substrate conversion in fixed- and fluid-bed reactors. Influence of enzyme microheterogeneity

AU - Malhotra, Arun

AU - Sadana, A.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.

AB - In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.

UR - http://www.scopus.com/inward/record.url?scp=0024951239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024951239&partnerID=8YFLogxK

M3 - Article

VL - 542

SP - 312

EP - 318

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -