Abstract
In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.
| Original language | English |
|---|---|
| Pages (from-to) | 312-318 |
| Number of pages | 7 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 542 |
| State | Published - Dec 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Effect of enzyme deactivation on substrate conversion in fixed- and fluid-bed reactors. Influence of enzyme microheterogeneity. / Malhotra, Arun; Sadana, A.
In: Annals of the New York Academy of Sciences, Vol. 542, 01.12.1989, p. 312-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of enzyme deactivation on substrate conversion in fixed- and fluid-bed reactors. Influence of enzyme microheterogeneity
AU - Malhotra, Arun
AU - Sadana, A.
PY - 1989/12/1
Y1 - 1989/12/1
N2 - In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.
AB - In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024951239&partnerID=8YFLogxK
M3 - Article
VL - 542
SP - 312
EP - 318
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -