Effect of Enzyme Deactivation on Substrate Conversion in Fixed‐ and Fluid‐Bed Reactors Influence of Enzyme Microheterogeneity


Research output: Contribution to journalArticle

2 Scopus citations


In an earlier paper, we presented a simple model to describe the behavior of a microheterogeneous enzyme undergoing first-order deactivation. This report looks at the behavior of such a heterogeneous enzyme in fixed- and fluid-bed reactors. Our studies indicate that microheterogeneity does influence deactivation behavior even when present in small quantities. However, the models presented should be used with caution. For instance, a stabilizing effect as seen with microheterogeneity can be caused by other factors such as preparative/immobilization procedures, chemical effects, etc. Therefore, these models and the conclusions should be used only if physical evidence of microheterogeneity is seen in an enzyme sample.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Dec 1988
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this