Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinomas in a transgenic mouse model

Yumi Yokoyama, Jeffrey E. Green, Vikas P. Sukhatme, S. Ramakrishnan

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A transgenic mouse model was used to evaluate the effect of endostatin treatment on spontaneous tumorigenesis. In this model system, female mice develop multiple mammary adenocarcinomas and male mice develop prostate cancer. Female mice treated with mouse endostatin during a 12-15-week period showed delayed tumor development by 4-6 weeks and significantly decreased tumor burden. Furthermore, endostatin treatment reduced the number of malignant lesions per mouse. In a separate set of experiments, male mice treated with endostatin showed a survival advantage, and their life spans were prolonged by 10.5 weeks over control animals. These data demonstrate that mouse endostatin is effective in delaying spontaneous tumor development and growth.

Original languageEnglish (US)
Pages (from-to)4362-4365
Number of pages4
JournalCancer Research
Volume60
Issue number16
StatePublished - Aug 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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