Effect of donepezil on motor and cognitive function in Huntington disease

E. Cubo, K. M. Shannon, D. Tracy, J. A. Jaglin, B. A. Bernard, J. Wuu, S. E. Leurgans

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.

Original languageEnglish (US)
Pages (from-to)1268-1271
Number of pages4
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Cubo, E., Shannon, K. M., Tracy, D., Jaglin, J. A., Bernard, B. A., Wuu, J., & Leurgans, S. E. (2006). Effect of donepezil on motor and cognitive function in Huntington disease. Neurology, 67(7), 1268-1271. https://doi.org/10.1212/01.wnl.0000238106.10423.00