Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation

A. Bancalari, Eduardo Bancalari, D. Hehre, C. Suguihara, T. Gerhardt, R. N. Goldberg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In order to evaluate the effect of distal endotracheal bias flow during HFOV on PaCO2 we studied adult rabbits with normal lungs and those who had meconium-induced lung dysfunction. Animals were studied while 1.0, 1.4 and 1.8 ml/kg tidal volumes (V(T)) were delivered by a high frequency oscillator. In animals with normal lungs and a 1.0 liter/min distal bias flow, the PaCO2 decreased significantly (p<0.01) with all V(T) used. In animals with meconium installation the decrease in PaCO2 was also significant (p<0.05) at all combinations of V(T) and distal bias flow. The higher the distal bias flow the more pronounced was the lowering effect on PaCO2. We conclude that during HFOV it is possible to improve CO2 elimination using small additional bias flow delivered near the tip of the endotracheal tube in animals with normal and abnormal lung function. This may allow adequate alveolar ventilation with even smaller V(T), thus reducing the risk of barotrauma.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalBiology of the Neonate
Volume53
Issue number2
StatePublished - Jan 1 1988

Fingerprint

High-Frequency Ventilation
Meconium
Lung
Barotrauma
Tidal Volume
Ventilation
Rabbits

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Bancalari, A., Bancalari, E., Hehre, D., Suguihara, C., Gerhardt, T., & Goldberg, R. N. (1988). Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation. Biology of the Neonate, 53(2), 61-67.

Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation. / Bancalari, A.; Bancalari, Eduardo; Hehre, D.; Suguihara, C.; Gerhardt, T.; Goldberg, R. N.

In: Biology of the Neonate, Vol. 53, No. 2, 01.01.1988, p. 61-67.

Research output: Contribution to journalArticle

Bancalari, A, Bancalari, E, Hehre, D, Suguihara, C, Gerhardt, T & Goldberg, RN 1988, 'Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation', Biology of the Neonate, vol. 53, no. 2, pp. 61-67.
Bancalari A, Bancalari E, Hehre D, Suguihara C, Gerhardt T, Goldberg RN. Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation. Biology of the Neonate. 1988 Jan 1;53(2):61-67.
Bancalari, A. ; Bancalari, Eduardo ; Hehre, D. ; Suguihara, C. ; Gerhardt, T. ; Goldberg, R. N. / Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation. In: Biology of the Neonate. 1988 ; Vol. 53, No. 2. pp. 61-67.
@article{4dcb31c1177c4eebb7002c7d3ba235f7,
title = "Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation",
abstract = "In order to evaluate the effect of distal endotracheal bias flow during HFOV on PaCO2 we studied adult rabbits with normal lungs and those who had meconium-induced lung dysfunction. Animals were studied while 1.0, 1.4 and 1.8 ml/kg tidal volumes (V(T)) were delivered by a high frequency oscillator. In animals with normal lungs and a 1.0 liter/min distal bias flow, the PaCO2 decreased significantly (p<0.01) with all V(T) used. In animals with meconium installation the decrease in PaCO2 was also significant (p<0.05) at all combinations of V(T) and distal bias flow. The higher the distal bias flow the more pronounced was the lowering effect on PaCO2. We conclude that during HFOV it is possible to improve CO2 elimination using small additional bias flow delivered near the tip of the endotracheal tube in animals with normal and abnormal lung function. This may allow adequate alveolar ventilation with even smaller V(T), thus reducing the risk of barotrauma.",
author = "A. Bancalari and Eduardo Bancalari and D. Hehre and C. Suguihara and T. Gerhardt and Goldberg, {R. N.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "53",
pages = "61--67",
journal = "Neonatology",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Effect of distal endotracheal bias flow on PaCO2 during high frequency oscillatory ventilation

AU - Bancalari, A.

AU - Bancalari, Eduardo

AU - Hehre, D.

AU - Suguihara, C.

AU - Gerhardt, T.

AU - Goldberg, R. N.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - In order to evaluate the effect of distal endotracheal bias flow during HFOV on PaCO2 we studied adult rabbits with normal lungs and those who had meconium-induced lung dysfunction. Animals were studied while 1.0, 1.4 and 1.8 ml/kg tidal volumes (V(T)) were delivered by a high frequency oscillator. In animals with normal lungs and a 1.0 liter/min distal bias flow, the PaCO2 decreased significantly (p<0.01) with all V(T) used. In animals with meconium installation the decrease in PaCO2 was also significant (p<0.05) at all combinations of V(T) and distal bias flow. The higher the distal bias flow the more pronounced was the lowering effect on PaCO2. We conclude that during HFOV it is possible to improve CO2 elimination using small additional bias flow delivered near the tip of the endotracheal tube in animals with normal and abnormal lung function. This may allow adequate alveolar ventilation with even smaller V(T), thus reducing the risk of barotrauma.

AB - In order to evaluate the effect of distal endotracheal bias flow during HFOV on PaCO2 we studied adult rabbits with normal lungs and those who had meconium-induced lung dysfunction. Animals were studied while 1.0, 1.4 and 1.8 ml/kg tidal volumes (V(T)) were delivered by a high frequency oscillator. In animals with normal lungs and a 1.0 liter/min distal bias flow, the PaCO2 decreased significantly (p<0.01) with all V(T) used. In animals with meconium installation the decrease in PaCO2 was also significant (p<0.05) at all combinations of V(T) and distal bias flow. The higher the distal bias flow the more pronounced was the lowering effect on PaCO2. We conclude that during HFOV it is possible to improve CO2 elimination using small additional bias flow delivered near the tip of the endotracheal tube in animals with normal and abnormal lung function. This may allow adequate alveolar ventilation with even smaller V(T), thus reducing the risk of barotrauma.

UR - http://www.scopus.com/inward/record.url?scp=0023854432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023854432&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 61

EP - 67

JO - Neonatology

JF - Neonatology

SN - 1661-7800

IS - 2

ER -