Effect of dexamethasone on vascular function in RIF-1 tumors

Paul G Braunschweiger, L. M. Schiffer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The present series of experiments was conducted to determine the effect of dexamethasone on vascular function and cell proliferation in s.c. RIF-1 tumors. 125I-BSA, 51Cr-EDTA dilution techniques were used to evaluate dexamethasone induced changes in tumor plasma water, capillary permeability, and extracellular water volumes, while 59Fe and 51Cr labeled erythrocyte techniques were used to assess changes in tumor exchangeable erythrocyte volumes. 86RbCl distribution studies were also conducted to evaluate vascular perfusion in RIF-1 tumors after dexamethasone treatment. In this corticosteroid receptor containing tumor model, dexamethasone had profound effects on all of the measured parameters of vascular function. Reduced tumor cell proliferation after dexamethasone treatments was accompanied by reduced capillary permeability, reduced interstitial water volumes, increased plasma volumes, and reduced vascular perfusion. Serial studies after dexamethasone treatments indicated that increases in vascular perfusion preceded proliferative recovery. Intervals of maximal [3H]thymidine labeling after dexamethasone were characterized by transient increases in capillary permeability, interstitial water volumes, and tumor erythrocyte exchange with the general circulation. At intervals of maximal cell proliferation (36-48 h after dex) 86RbCl distribution in tumors was about 3 times that seen in untreated controls. The results seem to indicate that, as in edematous normal tissues, dexamethasone can have profound effects on vascular function and water compartmentalization in RIF-1 tumors.

Original languageEnglish
Pages (from-to)3299-3303
Number of pages5
JournalCancer Research
Volume46
Issue number7
StatePublished - Jan 1 1986
Externally publishedYes

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Dexamethasone
Blood Vessels
Neoplasms
Capillary Permeability
Water
Erythrocyte Volume
Perfusion
Cell Proliferation
Indicator Dilution Techniques
Plasma Volume
Steroid Receptors
Tumor Burden
Edetic Acid
Thymidine
Erythrocytes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Braunschweiger, P. G., & Schiffer, L. M. (1986). Effect of dexamethasone on vascular function in RIF-1 tumors. Cancer Research, 46(7), 3299-3303.

Effect of dexamethasone on vascular function in RIF-1 tumors. / Braunschweiger, Paul G; Schiffer, L. M.

In: Cancer Research, Vol. 46, No. 7, 01.01.1986, p. 3299-3303.

Research output: Contribution to journalArticle

Braunschweiger, PG & Schiffer, LM 1986, 'Effect of dexamethasone on vascular function in RIF-1 tumors', Cancer Research, vol. 46, no. 7, pp. 3299-3303.
Braunschweiger PG, Schiffer LM. Effect of dexamethasone on vascular function in RIF-1 tumors. Cancer Research. 1986 Jan 1;46(7):3299-3303.
Braunschweiger, Paul G ; Schiffer, L. M. / Effect of dexamethasone on vascular function in RIF-1 tumors. In: Cancer Research. 1986 ; Vol. 46, No. 7. pp. 3299-3303.
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