Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

Richard C. Veith, Nancy Lewis, Janis I. Langohr, M. Michele Murburg, E. Alexandra Ashleigh, Sonia Castillo, Elaine R. Peskind, Marcella Pascualy, Garth Bissette, Charles B. Nemeroff, Murray A. Raskind

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalPsychiatry Research
Volume46
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

Keywords

  • cortisol
  • hypothalamic-pituitary-adrenal axis
  • Norepinephrine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Fingerprint Dive into the research topics of 'Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects'. Together they form a unique fingerprint.

  • Cite this

    Veith, R. C., Lewis, N., Langohr, J. I., Murburg, M. M., Ashleigh, E. A., Castillo, S., Peskind, E. R., Pascualy, M., Bissette, G., Nemeroff, C. B., & Raskind, M. A. (1993). Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. Psychiatry Research, 46(1), 1-8. https://doi.org/10.1016/0165-1781(93)90002-X