Abstract
To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Psychiatry Research |
| Volume | 46 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
Fingerprint
Keywords
- cortisol
- hypothalamic-pituitary-adrenal axis
- Norepinephrine
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. / Veith, Richard C.; Lewis, Nancy; Langohr, Janis I.; Murburg, M. Michele; Ashleigh, E. Alexandra; Castillo, Sonia; Peskind, Elaine R.; Pascualy, Marcella; Bissette, Garth; Nemeroff, Charles; Raskind, Murray A.
In: Psychiatry Research, Vol. 46, No. 1, 01.01.1993, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects
AU - Veith, Richard C.
AU - Lewis, Nancy
AU - Langohr, Janis I.
AU - Murburg, M. Michele
AU - Ashleigh, E. Alexandra
AU - Castillo, Sonia
AU - Peskind, Elaine R.
AU - Pascualy, Marcella
AU - Bissette, Garth
AU - Nemeroff, Charles
AU - Raskind, Murray A.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.
AB - To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.
KW - cortisol
KW - hypothalamic-pituitary-adrenal axis
KW - Norepinephrine
UR - http://www.scopus.com/inward/record.url?scp=0027536051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027536051&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(93)90002-X
DO - 10.1016/0165-1781(93)90002-X
M3 - Article
C2 - 8464952
AN - SCOPUS:0027536051
VL - 46
SP - 1
EP - 8
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1
ER -