Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

Richard C. Veith; Nancy Lewis; Janis I. Langohr; M. Michele Murburg; E. Alexandra Ashleigh; Sonia Castillo; Elaine R. Peskind; Marcella Pascualy; Garth Bissette; Charles B. Nemeroff; Murray A. Raskind

doi:10.1016/0165-1781(93)90002-X

Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects

Richard C. Veith, Nancy Lewis, Janis I. Langohr, M. Michele Murburg, E. Alexandra Ashleigh, Sonia Castillo, Elaine R. Peskind, Marcella Pascualy, Garth Bissette, Charles B. Nemeroff, Murray A. Raskind

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Psychiatry Research
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(93)90002-X
State	Published - Jan 1993
Externally published	Yes

Keywords

cortisol
hypothalamic-pituitary-adrenal axis
Norepinephrine

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Psychology(all)

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Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. / Veith, Richard C.; Lewis, Nancy; Langohr, Janis I.; Murburg, M. Michele; Ashleigh, E. Alexandra; Castillo, Sonia; Peskind, Elaine R.; Pascualy, Marcella; Bissette, Garth; Nemeroff, Charles B.; Raskind, Murray A.

In: Psychiatry Research, Vol. 46, No. 1, 01.1993, p. 1-8.

Research output: Contribution to journal › Article › peer-review

Veith, Richard C. ; Lewis, Nancy ; Langohr, Janis I. ; Murburg, M. Michele ; Ashleigh, E. Alexandra ; Castillo, Sonia ; Peskind, Elaine R. ; Pascualy, Marcella ; Bissette, Garth ; Nemeroff, Charles B. ; Raskind, Murray A. / Effect of desipramine on cerebrospinal fluid concentrations of corticotropin-releasing factor in human subjects. In: Psychiatry Research. 1993 ; Vol. 46, No. 1. pp. 1-8.

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abstract = "To assess the effect of desipramine (DMI) on corticotropin-releasing-factor (CRF) activity in the central nervous system, we measured cerebrospinal fluid (CSF) concentrations of CRF in healthy volunteers following short-term administration of DMI or placebo. DMI administration for 2 days was associated with a significant dose-related reduction in CRF concentrations. There was a nonsignificant 6% reduction in CRF concentrations among the 10 subjects who received 50 mg DMI (△ CRF: -3±2 pg/ml) and a significant 14% fall in the CRF concentrations of the eight subjects who received 100 mg DMI (△ CRF: -8±3 pg/ml). The mean CSF concentration of CRF was unchanged in the six subjects randomized to placebo (△ CRF: 1±5 pg/ml). DMI administration had no effect on CSF norepinephrine concentrations (n = 24) or on plasma cortisol (n = 25). We conclude that short-term administration of DMI in healthy volunteers is associated with a dose-related reduction in CSF concentrations of CRF.",

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