Effect of deep brain stimulation on parkinson's nonmotor symptoms following unilateral DBS: A pilot study

Nelson Hwynn, Ihtsham Ul Haq, Irene A. Malaty, Andrew S. Resnick, Yunfeng Dai, Kelly D. Foote, Hubert H. Fernandez, Samuel S. Wu, Genko Oyama, Charles E. Jacobson, Sung K. Kim, Michael S. Okun

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Parkinsons disease (PD) management has traditionally focused largely on motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are effective treatments for motor symptoms. Nonmotor symptoms (NMSs) may also profoundly affect the quality of life. The purpose of this pilot study was to evaluate NMS changes pre- and post-DBS utilizing two recently developed questionnaires. Methods. NMS-Q (questionnaire) and NMS-S (scale) were administered to PD patients before/after unilateral DBS (STN/GPi targets). Results. Ten PD patients (9 STN implants, 1 GPi implant) were included. The three most frequent NMS symptoms identified utilizing NMS-Q in pre-surgical patients were gastrointestinal (100%), sleep (100%), and urinary (90%). NMS sleep subscore significantly decreased (-1.6 points ± 1.8, P = 0.03). The three most frequent NMS symptoms identified in pre-surgical patients using NMS-S were gastrointestinal (90%), mood (80%), and cardiovascular (80%). The largest mean decrease of NMS scores was seen in miscellaneous symptoms (pain, anosmia, weight change, and sweating) (-7 points ± 8.7), and cardiovascular/falls (-1.9, P = 0.02). Conclusion. Non-motor symptoms improved on two separate questionnaires following unilateral DBS for PD. Future studies are needed to confirm these findings and determine their clinical significance as well as to examine the strengths/weaknesses of each questionnaire/scale.

Original languageEnglish (US)
Article number507416
JournalParkinson's Disease
DOIs
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

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