Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

N. Hagino, O. Nakamoto, Y. Kunz, A. Arimura, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalActa Endocrinologica
Volume91
Issue number2
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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    Hagino, N., Nakamoto, O., Kunz, Y., Arimura, A., Coy, D. H., & Schally, A. V. (1979). Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon. Acta Endocrinologica, 91(2), 217-223.