Abstract
The effect of cyproheptadine (Cypro) and Placebo administration on insulin secretion and glucose utilization following i.v. glucose (IVGTT) was evaluated in 8 normal, 7 diabetic and 8 acromegalic subjects. Five of the diabetic subjects had overt diabetes and 2 of the diabetic subjects had 'chemical' diabetes (oral GTT). One of the acromegalic subjects had overt diabetes, while one had borderline glucose tolerance and 6 had normal glucose tolerance (oral GTT). Cypro increased insulin secretion in the acromegalic but not in the diabetic or normal subjects. Methysergide (Methy) increased insulin secretion in acromegalic and diabetic subjects but not in normal subjects. Methy and Cypro both increased insulin secretion in the same acromegalic subjects. None of the 3 groups of subjects had a modification in insulin secretion following Placebo administration. Neither Placebo, Cypro or Methy altered the glucose utilization rate constant (KG). There was no change in insulin half life or tissue sensitivity to insulin from Cypro (normal and acromegalic subjects) or Methy (normal subjects) administration. Despite their increase in insulin secretion in response to serotonin antagonists, acromegalic subjects have normal urinary 5 hydroxyindoleacetic acid excretion and normal serum serotonin concentrations. Their response cannot therefore be attributed to a generalized overproduction of serotonin.
| Original language | English |
|---|---|
| Pages (from-to) | 279-283 |
| Number of pages | 5 |
| Journal | Hormone and Metabolic Research |
| Volume | 7 |
| Issue number | 4 |
| State | Published - Dec 1 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Effect of cyproheptadine administration on insulin secretion in acromegalic, diabetic and normal subjects. / Feldman, J. M.; Bivens, C. H.; Skyler, Jay S; Lebovitz, H. E.
In: Hormone and Metabolic Research, Vol. 7, No. 4, 01.12.1975, p. 279-283.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of cyproheptadine administration on insulin secretion in acromegalic, diabetic and normal subjects
AU - Feldman, J. M.
AU - Bivens, C. H.
AU - Skyler, Jay S
AU - Lebovitz, H. E.
PY - 1975/12/1
Y1 - 1975/12/1
N2 - The effect of cyproheptadine (Cypro) and Placebo administration on insulin secretion and glucose utilization following i.v. glucose (IVGTT) was evaluated in 8 normal, 7 diabetic and 8 acromegalic subjects. Five of the diabetic subjects had overt diabetes and 2 of the diabetic subjects had 'chemical' diabetes (oral GTT). One of the acromegalic subjects had overt diabetes, while one had borderline glucose tolerance and 6 had normal glucose tolerance (oral GTT). Cypro increased insulin secretion in the acromegalic but not in the diabetic or normal subjects. Methysergide (Methy) increased insulin secretion in acromegalic and diabetic subjects but not in normal subjects. Methy and Cypro both increased insulin secretion in the same acromegalic subjects. None of the 3 groups of subjects had a modification in insulin secretion following Placebo administration. Neither Placebo, Cypro or Methy altered the glucose utilization rate constant (KG). There was no change in insulin half life or tissue sensitivity to insulin from Cypro (normal and acromegalic subjects) or Methy (normal subjects) administration. Despite their increase in insulin secretion in response to serotonin antagonists, acromegalic subjects have normal urinary 5 hydroxyindoleacetic acid excretion and normal serum serotonin concentrations. Their response cannot therefore be attributed to a generalized overproduction of serotonin.
AB - The effect of cyproheptadine (Cypro) and Placebo administration on insulin secretion and glucose utilization following i.v. glucose (IVGTT) was evaluated in 8 normal, 7 diabetic and 8 acromegalic subjects. Five of the diabetic subjects had overt diabetes and 2 of the diabetic subjects had 'chemical' diabetes (oral GTT). One of the acromegalic subjects had overt diabetes, while one had borderline glucose tolerance and 6 had normal glucose tolerance (oral GTT). Cypro increased insulin secretion in the acromegalic but not in the diabetic or normal subjects. Methysergide (Methy) increased insulin secretion in acromegalic and diabetic subjects but not in normal subjects. Methy and Cypro both increased insulin secretion in the same acromegalic subjects. None of the 3 groups of subjects had a modification in insulin secretion following Placebo administration. Neither Placebo, Cypro or Methy altered the glucose utilization rate constant (KG). There was no change in insulin half life or tissue sensitivity to insulin from Cypro (normal and acromegalic subjects) or Methy (normal subjects) administration. Despite their increase in insulin secretion in response to serotonin antagonists, acromegalic subjects have normal urinary 5 hydroxyindoleacetic acid excretion and normal serum serotonin concentrations. Their response cannot therefore be attributed to a generalized overproduction of serotonin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016838223&partnerID=8YFLogxK
M3 - Article
C2 - 1150128
AN - SCOPUS:0016838223
VL - 7
SP - 279
EP - 283
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 4
ER -