TY - JOUR
T1 - Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis1
AU - Suguihara, Cleide
AU - Goldberg, Ronald N.
AU - Hehre, Dorothy
AU - Bancalari, Aldo
AU - Bancalari, Eduardo
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1987/10
Y1 - 1987/10
N2 - The effects of the cyclooxygenase inhibitor, indomethacin, and the leukotriene receptor antagonist, FPL 57231, on changes in dynamic lung compliance and pulmonary resistance associated with a 1-h infusion of live group B streptococci were evaluated in mechanically ventilated piglets. To define mediators of early changes in lung function, animals were given an infusion of either FPL 57231 or indomethacin beginning 15 min after the infusion of group B streptococci was begun. These groups were compared to an untreated group who received only group B streptococci. Within 15 min of starting the bacterial infusion, all groups showed significant increases in pulmonary artery pressure, pulmonary artery wedge pressure, total pulmonary resistance, transpulmonary pressure, and thromboxane B2, and decreases in tidal volume, dynamic lung compliance, and PaO2. After treatment with indomethacin there were significant decreases in pulmonary artery pressure (mean ± SEM; 48 ± 1 to 22 ± 3 mm Hg, p<0.001), pulmonary artery wedge pressure (7.5 ± 1.3 to 2.2 ± 0.4 mm Hg, p < 0.001) and thromboxane B2 (6.51 ± 1.56 to 1.01 ± 0.27 ng/ml, p < 0.01) and an increase in dynamic lung compliance (1.10 ± 0.10 to 1.28 ± 0.14 ml/cm H2O/kg, p < 0.01) over the study period. Total pulmonary resistance decreased significantly (18.7 ± 1.8 to 15.7 ± 1.5 cm H2O/liter/s, p <0.02) only at 60 min. In animals treated with FPL 57231 only pulmonary artery pressure (46 ± 3 to 30 ± 2 mm Hg, p < 0.05) and pulmonary artery wedge pressure (7.5 ± 0.8 to 4.0 ± 0.9 mm Hg, p < 0.01) decreased. These data suggest that cyclooxygenase products of arachidonic acid metabolism play a role in the early changes in pulmonary mechanics in group B streptococci sepsis.
AB - The effects of the cyclooxygenase inhibitor, indomethacin, and the leukotriene receptor antagonist, FPL 57231, on changes in dynamic lung compliance and pulmonary resistance associated with a 1-h infusion of live group B streptococci were evaluated in mechanically ventilated piglets. To define mediators of early changes in lung function, animals were given an infusion of either FPL 57231 or indomethacin beginning 15 min after the infusion of group B streptococci was begun. These groups were compared to an untreated group who received only group B streptococci. Within 15 min of starting the bacterial infusion, all groups showed significant increases in pulmonary artery pressure, pulmonary artery wedge pressure, total pulmonary resistance, transpulmonary pressure, and thromboxane B2, and decreases in tidal volume, dynamic lung compliance, and PaO2. After treatment with indomethacin there were significant decreases in pulmonary artery pressure (mean ± SEM; 48 ± 1 to 22 ± 3 mm Hg, p<0.001), pulmonary artery wedge pressure (7.5 ± 1.3 to 2.2 ± 0.4 mm Hg, p < 0.001) and thromboxane B2 (6.51 ± 1.56 to 1.01 ± 0.27 ng/ml, p < 0.01) and an increase in dynamic lung compliance (1.10 ± 0.10 to 1.28 ± 0.14 ml/cm H2O/kg, p < 0.01) over the study period. Total pulmonary resistance decreased significantly (18.7 ± 1.8 to 15.7 ± 1.5 cm H2O/liter/s, p <0.02) only at 60 min. In animals treated with FPL 57231 only pulmonary artery pressure (46 ± 3 to 30 ± 2 mm Hg, p < 0.05) and pulmonary artery wedge pressure (7.5 ± 0.8 to 4.0 ± 0.9 mm Hg, p < 0.01) decreased. These data suggest that cyclooxygenase products of arachidonic acid metabolism play a role in the early changes in pulmonary mechanics in group B streptococci sepsis.
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U2 - 10.1203/00006450-198710000-00024
DO - 10.1203/00006450-198710000-00024
M3 - Article
C2 - 3120143
AN - SCOPUS:0023203561
VL - 22
SP - 478
EP - 482
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 4
ER -