Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH

L. Debeljuk, V. Rettori, S. Goijman, D. H. Coy, A. V. Schally

Research output: Contribution to journalArticle

Abstract

The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.

Original languageEnglish (US)
Pages (from-to)345-348
Number of pages4
JournalArchives of Andrology
Volume5
Issue number4
DOIs
StatePublished - Jan 1980
Externally publishedYes

Keywords

  • Cycloheximide and LH-RH
  • Superactive analog

ASJC Scopus subject areas

  • Endocrinology

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