Abstract
The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 345-348 |
| Number of pages | 4 |
| Journal | Archives of Andrology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1980 |
| Externally published | Yes |
Keywords
- Cycloheximide and LH-RH
- Superactive analog
ASJC Scopus subject areas
- Endocrinology
Fingerprint Dive into the research topics of 'Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH'. Together they form a unique fingerprint.
Cite this
Debeljuk, L., Rettori, V., Goijman, S., Coy, D. H., & Schally, A. V. (1980). Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH. Archives of Andrology, 5(4), 345-348. https://doi.org/10.3109/01485018008987004