Abstract
The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.
| Original language | English |
|---|---|
| Pages (from-to) | 345-348 |
| Number of pages | 4 |
| Journal | Archives of Andrology |
| Volume | 5 |
| Issue number | 4 |
| State | Published - Dec 1 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
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Effect of cycloheximide on the LH release induced by a superactive analog of LH-RH. / Debeljuk, L.; Rettori, V.; Goijman, S.; Coy, D. H.; Schally, Andrew V.
In: Archives of Andrology, Vol. 5, No. 4, 01.12.1980, p. 345-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of cycloheximide on the LH release induced by a superactive analog of LH-RH
AU - Debeljuk, L.
AU - Rettori, V.
AU - Goijman, S.
AU - Coy, D. H.
AU - Schally, Andrew V
PY - 1980/12/1
Y1 - 1980/12/1
N2 - The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.
AB - The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019160511&partnerID=8YFLogxK
M3 - Article
C2 - 7004364
AN - SCOPUS:0019160511
VL - 5
SP - 345
EP - 348
JO - Systems Biology in Reproductive Medicine
JF - Systems Biology in Reproductive Medicine
SN - 1939-6376
IS - 4
ER -