Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH

L. Debeljuk; V. Rettori; S. Goijman; D. H. Coy; A. V. Schally

doi:10.3109/01485018008987004

Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH

L. Debeljuk, V. Rettori, S. Goijman, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.

Original language	English (US)
Pages (from-to)	345-348
Number of pages	4
Journal	Archives of Andrology
Volume	5
Issue number	4
DOIs	https://doi.org/10.3109/01485018008987004
State	Published - Jan 1980
Externally published	Yes

Keywords

Cycloheximide and LH-RH
Superactive analog

ASJC Scopus subject areas

Endocrinology

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10.3109/01485018008987004

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title = "Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH",

abstract = "The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.",

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author = "L. Debeljuk and V. Rettori and S. Goijman and Coy, {D. H.} and Schally, {A. V.}",

year = "1980",

month = jan,

doi = "10.3109/01485018008987004",

language = "English (US)",

volume = "5",

pages = "345--348",

journal = "Systems Biology in Reproductive Medicine",

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AU - Debeljuk, L.

AU - Rettori, V.

AU - Goijman, S.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1980/1

Y1 - 1980/1

N2 - The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.

AB - The effect of cycloheximide on the pituitary response to a superactive analog of LH-RH (D-Ala-6-des-gly-10-LH-RH-ethylamide) was studied in intact male rats. Cycloheximide did not modify the LH release induced by the LH-RH analog within 1 hr after its injection, but produced significant supression between 1 and 4 hr. It is concluded that the early release of LH observed after the administration of the analog occurs from the readily releasable pool of LH in the pitutary gland, which is not affected by cycloheximide. The subsequent LH release that can be suppressed by cycloheximide comes from the second pool of LH.

KW - Cycloheximide and LH-RH

KW - Superactive analog

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Effect of Cycloheximide on the LH Release Induced by a Superactive Analog of LH-RH

Abstract

Keywords

ASJC Scopus subject areas

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