Effect of chloramphenicol and thiamphenicol on the in vitro colony forming cell

Judith Ratzan, M. A S Moore, Adel A Yunis

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Abstract

The effect of chloramphenicol (CAP) and a chloramphenicol analog, thiamphenicol (TAP), on the growth of bone marrow colony forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation. The inhibition appears to be reversible within a 24 h period of cell and drug contact. In addition to their effect on colony forming cell (CFC) proliferation, CAP and TAP appear to influence the type of CFC differentiation resulting in predominance of macrophage colonies.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalBlood
Volume43
Issue number3
StatePublished - 1974

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ASJC Scopus subject areas

  • Hematology

Cite this

Ratzan, J., Moore, M. A. S., & Yunis, A. A. (1974). Effect of chloramphenicol and thiamphenicol on the in vitro colony forming cell. Blood, 43(3), 363-369.