The effect of chloramphenicol (CAP) and a chloramphenicol analog, thiamphenicol (TAP), on the growth of bone marrow colony forming cells in agar was investigated. At concentrations within therapeutic range, both drugs cause a marked reduction in the number of colonies and in the size of aggregates, indicating suppressed cellular proliferation. The inhibition appears to be reversible within a 24 h period of cell and drug contact. In addition to their effect on colony forming cell (CFC) proliferation, CAP and TAP appear to influence the type of CFC differentiation resulting in predominance of macrophage colonies.
ASJC Scopus subject areas
- Cell Biology