Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice

Xie Xiao Bin, Katerina Wolf, Thomas Schaffner, Raffaele Malinverni

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin. (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.

Original languageEnglish (US)
Pages (from-to)1761-1764
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume44
Issue number6
DOIs
StatePublished - Jun 20 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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