Effect of Anti-Vascular Endothelial Growth Factor Therapy on Corneal Nerves

Raquel Goldhardt, Hatim Ismail M. Batawi, Mark Rosenblatt, Ivonne V. Lollett, Jasmine J. Park, Anat Galor

Research output: Contribution to journalArticle

Abstract

PURPOSE: Vascular endothelial growth factor (VEGF) is a trophic factor for corneal nerves (CNs). Despite its widespread use to treat a variety of retinal diseases, the effect of repetitive intravitreal (IV) anti-VEGF injections on CN is not known. METHODS: Retrospective case-control study. CN parameters were compared between eyes in 39 individuals who received anti-VEGF injections in one eye only. Next, we compared CN parameters between 50 eyes of 50 individuals with a history of IV anti-VEGF injections and 80 eyes of 80 individuals without a history of injection. In vivo confocal microscopic examination was conducted using the ConfoScan 4. Images were analyzed by the Corneal Nerve Analysis tool. Paired and independent t test methodologies were used to compare nerve parameters, and multivariable linear regression analysis was performed to control for potential confounders. RESULTS: In 39 patients (own controls), eyes with a history of IV injection had lower CN length density, total length, nerve fibers, bifurcations, and branches (P < 0.005) compared to the fellow eyes without injection. Similar findings were seen in the eyes of 50 individuals with a history of injection compared to 80 individuals without injection. A history of IV injections and ethnicity remained significantly associated with the CN length density and explained 32% of the variability (R = 0.56). CONCLUSIONS: We found decreased CN parameters in eyes with a history of anti-VEGF injections compared to eyes without such a history.

Original languageEnglish (US)
Pages (from-to)559-564
Number of pages6
JournalCornea
Volume38
Issue number5
DOIs
StatePublished - May 1 2019

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Vascular Endothelial Growth Factor A
Injections
Intravitreal Injections
Therapeutics
Retinal Diseases
Nerve Fibers
Case-Control Studies
Linear Models
History
Regression Analysis

ASJC Scopus subject areas

  • Ophthalmology

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Effect of Anti-Vascular Endothelial Growth Factor Therapy on Corneal Nerves. / Goldhardt, Raquel; Batawi, Hatim Ismail M.; Rosenblatt, Mark; Lollett, Ivonne V.; Park, Jasmine J.; Galor, Anat.

In: Cornea, Vol. 38, No. 5, 01.05.2019, p. 559-564.

Research output: Contribution to journalArticle

Goldhardt, Raquel ; Batawi, Hatim Ismail M. ; Rosenblatt, Mark ; Lollett, Ivonne V. ; Park, Jasmine J. ; Galor, Anat. / Effect of Anti-Vascular Endothelial Growth Factor Therapy on Corneal Nerves. In: Cornea. 2019 ; Vol. 38, No. 5. pp. 559-564.
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