Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL- lpr lpr mice

Gary S. Gilkeson, Robert Spurney, Thomas M. Coffman, Roger Kurlander, Phillip Ruiz, David S. Pisetsky

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27 Scopus citations

Abstract

MRL- lpr lpr mice develop an inflammatory arthritis in association with other manifestations of autoimmunity. Although a variety of immune cell disturbances have been described in these mice, the relationship of these abnormalities to the pathogenesis of arthritis has not yet been determined; the role of T cells is especially unclear since synovial hypertrophy and joint erosions have been noted in some studies in the absence of a significant T cell infiltrate. Therefore, to determine if T cells are required for arthritis in MRL- lpr lpr mice, we evaluated the effects of prolonged treatment with a monoclonal anti-CD4 antibody. Knee joints from treated mice had markedly reduced arthritis compared to saline-treated control animals as measured by the degree of synovial hypertrophy and inflammation. Nephritis in these mice was concomitantly reduced. In contrast, rheumatoid factor levels were not affected by CD4+ cell depletion, despite significant effects on anti-DNA. These results indicate that in MRL- lpr lpr mice anti-CD4 therapy can inhibit arthritis, suggesting an important role of T cells in the pathogenesis of this lesion.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalClinical Immunology and Immunopathology
Volume64
Issue number2
DOIs
StatePublished - Aug 1992

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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