Effect of anesthetic technique on acute formalin-induced pain in mice

E. S. Fu, J. E. Scharf

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background and Objectives. The aim of this study was to determine if anesthetic technique influences the degree of acute formalin-induced pain in mice. Methods. Mice were randomized to receive either combined spinal/general anesthesia or general anesthesia prior to a subcutaneous injection of formalin in a hindpaw. The mice in the combined spinal/general anesthesia group received halothane anesthesia and subarachnoid lidocaine. The mice in the general anesthesia group received halothane anesthesia only. After the mice recovered from anesthesia, paw-licking behavior was recorded for 1 hour. A statistical comparison was made using analysis of variance and the Kolmogorov-Smirnov test. Results. The mice in the combined spinal/general anesthesia group (n = 20) had a significantly shorter time to first paw lick (mean ± SD) after formalin injection compared to the mice in the general anesthesia group (n = 20) (16.1 ± 4.5 vs. 22.1 ± 6.3 min, P = .002). No difference was observed in the number of paw licks in the mice receiving either combined spinal/general anesthesia or general anesthesia (40 ± 15 vs. 44 ± 18, P = .47). No difference was observed in the duration of paw licking in either group (231 ± 76 vs. 237 ± 124 s, P = .84). Conclusions. The administration of a pre-emptive subarachnoid lidocaine block in the combined spinal/general anesthesia group did not reduce the degree of formalin- induced paw-licking behavior. Combined spinal/general anesthesia did not decrease acute formalin-induced pain in mice.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalRegional Anesthesia
Volume20
Issue number3
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • formalin-induced pain
  • pre-emptive analgesia
  • regional anesthesia
  • spinal anesthesia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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