Effect of an inhaled glucocorticoid on endothelial function in healthy smokers

Eliana Mendes, Gabor Horvath, Patricia Rebolledo, Maria Elena Monzon, S. Marina Casalino-Matsuda, Adam Wanner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cigarette smoking is associated with attenuated endothelium-dependent vasodilation (endothelial dysfunction) in the systemic circulation, including the airway circulation. We wished to determine whether an inhaled corticosteroid could restore endothelial function in the airway of lung-healthy current smokers, ex-smokers, and nonsmokers. We measured baseline airway blood flow (Q̇aw) and Q̇aw reactivity to inhaled albuterol as an index of endothelium-dependent vasodilation and to sublingual nitroglycerin as an index of endothelium-independent vasodilation in lung-healthy current smokers, ex-smokers, and nonsmokers. Current smokers were then treated with inhaled fluticasone for 3 wk, and all measurements were repeated after fluticasone treatment and after a subsequent 3-wk fluticasone washout period. Baseline mean Q̇aw and endothelium-independent Q̇aw reactivity were similar in the three groups. Mean endothelium-dependent Q̇aw reactivity was 49.5% in nonsmokers, 42.7% in ex-smokers, and 10.8% in current smokers (P < 0.05 vs. nonsmokers). In current smokers, mean baseline Q̇aw was unchanged after fluticasone treatment, but endothelium-dependent Q̇aw reactivity significantly increased to 34.9%. Q̇aw reactivity was again blunted after fluticasone washout. Endothelial dysfunction, as assessed by vascular reactivity, can be corrected with an inhaled corticosteroid in the airway of lung-healthy current smokers. This proof of concept can serve as the basis for future clinical investigations on the effect of glucocorticoids on endothelial function in smokers.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalJournal of Applied Physiology
Volume105
Issue number1
DOIs
StatePublished - Jul 1 2008

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Glucocorticoids
Endothelium
Vasodilation
Lung
Adrenal Cortex Hormones
Albuterol
Nitroglycerin
Blood Vessels
Smoking
Fluticasone

Keywords

  • Airway blood flow
  • Smoking

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of an inhaled glucocorticoid on endothelial function in healthy smokers. / Mendes, Eliana; Horvath, Gabor; Rebolledo, Patricia; Monzon, Maria Elena; Casalino-Matsuda, S. Marina; Wanner, Adam.

In: Journal of Applied Physiology, Vol. 105, No. 1, 01.07.2008, p. 54-57.

Research output: Contribution to journalArticle

Mendes, Eliana ; Horvath, Gabor ; Rebolledo, Patricia ; Monzon, Maria Elena ; Casalino-Matsuda, S. Marina ; Wanner, Adam. / Effect of an inhaled glucocorticoid on endothelial function in healthy smokers. In: Journal of Applied Physiology. 2008 ; Vol. 105, No. 1. pp. 54-57.
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