Abstract
Cigarette smoking is associated with attenuated endothelium-dependent vasodilation (endothelial dysfunction) in the systemic circulation, including the airway circulation. We wished to determine whether an inhaled corticosteroid could restore endothelial function in the airway of lung-healthy current smokers, ex-smokers, and nonsmokers. We measured baseline airway blood flow (Q̇aw) and Q̇aw reactivity to inhaled albuterol as an index of endothelium-dependent vasodilation and to sublingual nitroglycerin as an index of endothelium-independent vasodilation in lung-healthy current smokers, ex-smokers, and nonsmokers. Current smokers were then treated with inhaled fluticasone for 3 wk, and all measurements were repeated after fluticasone treatment and after a subsequent 3-wk fluticasone washout period. Baseline mean Q̇aw and endothelium-independent Q̇aw reactivity were similar in the three groups. Mean endothelium-dependent Q̇aw reactivity was 49.5% in nonsmokers, 42.7% in ex-smokers, and 10.8% in current smokers (P < 0.05 vs. nonsmokers). In current smokers, mean baseline Q̇aw was unchanged after fluticasone treatment, but endothelium-dependent Q̇aw reactivity significantly increased to 34.9%. Q̇aw reactivity was again blunted after fluticasone washout. Endothelial dysfunction, as assessed by vascular reactivity, can be corrected with an inhaled corticosteroid in the airway of lung-healthy current smokers. This proof of concept can serve as the basis for future clinical investigations on the effect of glucocorticoids on endothelial function in smokers.
| Original language | English |
|---|---|
| Pages (from-to) | 54-57 |
| Number of pages | 4 |
| Journal | Journal of Applied Physiology |
| Volume | 105 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2008 |
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Keywords
- Airway blood flow
- Smoking
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Effect of an inhaled glucocorticoid on endothelial function in healthy smokers. / Mendes, Eliana; Horvath, Gabor; Rebolledo, Patricia; Monzon, Maria Elena; Casalino-Matsuda, S. Marina; Wanner, Adam.
In: Journal of Applied Physiology, Vol. 105, No. 1, 01.07.2008, p. 54-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of an inhaled glucocorticoid on endothelial function in healthy smokers
AU - Mendes, Eliana
AU - Horvath, Gabor
AU - Rebolledo, Patricia
AU - Monzon, Maria Elena
AU - Casalino-Matsuda, S. Marina
AU - Wanner, Adam
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Cigarette smoking is associated with attenuated endothelium-dependent vasodilation (endothelial dysfunction) in the systemic circulation, including the airway circulation. We wished to determine whether an inhaled corticosteroid could restore endothelial function in the airway of lung-healthy current smokers, ex-smokers, and nonsmokers. We measured baseline airway blood flow (Q̇aw) and Q̇aw reactivity to inhaled albuterol as an index of endothelium-dependent vasodilation and to sublingual nitroglycerin as an index of endothelium-independent vasodilation in lung-healthy current smokers, ex-smokers, and nonsmokers. Current smokers were then treated with inhaled fluticasone for 3 wk, and all measurements were repeated after fluticasone treatment and after a subsequent 3-wk fluticasone washout period. Baseline mean Q̇aw and endothelium-independent Q̇aw reactivity were similar in the three groups. Mean endothelium-dependent Q̇aw reactivity was 49.5% in nonsmokers, 42.7% in ex-smokers, and 10.8% in current smokers (P < 0.05 vs. nonsmokers). In current smokers, mean baseline Q̇aw was unchanged after fluticasone treatment, but endothelium-dependent Q̇aw reactivity significantly increased to 34.9%. Q̇aw reactivity was again blunted after fluticasone washout. Endothelial dysfunction, as assessed by vascular reactivity, can be corrected with an inhaled corticosteroid in the airway of lung-healthy current smokers. This proof of concept can serve as the basis for future clinical investigations on the effect of glucocorticoids on endothelial function in smokers.
AB - Cigarette smoking is associated with attenuated endothelium-dependent vasodilation (endothelial dysfunction) in the systemic circulation, including the airway circulation. We wished to determine whether an inhaled corticosteroid could restore endothelial function in the airway of lung-healthy current smokers, ex-smokers, and nonsmokers. We measured baseline airway blood flow (Q̇aw) and Q̇aw reactivity to inhaled albuterol as an index of endothelium-dependent vasodilation and to sublingual nitroglycerin as an index of endothelium-independent vasodilation in lung-healthy current smokers, ex-smokers, and nonsmokers. Current smokers were then treated with inhaled fluticasone for 3 wk, and all measurements were repeated after fluticasone treatment and after a subsequent 3-wk fluticasone washout period. Baseline mean Q̇aw and endothelium-independent Q̇aw reactivity were similar in the three groups. Mean endothelium-dependent Q̇aw reactivity was 49.5% in nonsmokers, 42.7% in ex-smokers, and 10.8% in current smokers (P < 0.05 vs. nonsmokers). In current smokers, mean baseline Q̇aw was unchanged after fluticasone treatment, but endothelium-dependent Q̇aw reactivity significantly increased to 34.9%. Q̇aw reactivity was again blunted after fluticasone washout. Endothelial dysfunction, as assessed by vascular reactivity, can be corrected with an inhaled corticosteroid in the airway of lung-healthy current smokers. This proof of concept can serve as the basis for future clinical investigations on the effect of glucocorticoids on endothelial function in smokers.
KW - Airway blood flow
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=50649101737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50649101737&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.90334.2008
DO - 10.1152/japplphysiol.90334.2008
M3 - Article
C2 - 18467553
AN - SCOPUS:50649101737
VL - 105
SP - 54
EP - 57
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 1
ER -