Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats

L. Debeljuk; I. Torres-Aleman; A. V. Schally

doi:10.1016/0196-9781(85)90111-1

Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats

L. Debeljuk, I. Torres-Aleman, A. V. Schally

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe^1,2, D-Trp³,D-Arg⁶,D-Ala¹⁰) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.

Original language	English (US)
Pages (from-to)	463-465
Number of pages	3
Journal	Peptides
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(85)90111-1
State	Published - 1985
Externally published	Yes

Keywords

LH, Pituitary
LH, Prolactin

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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title = "Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats",

abstract = "The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.",

keywords = "LH, Pituitary, LH, Prolactin",

author = "L. Debeljuk and I. Torres-Aleman and Schally, {A. V.}",

note = "Funding Information: We thank the National Hormone and Pituitary Program (NHPP) for the gifts of materials used in radioimmunoassays, Miss Martha Sampson, Mrs. Elsa Winsor and Mrs. Meredith Mason-Garcia for their excellent technical assistance and Organon Scientific, Oss Holland for the supply of ORG 30276. This work was supported by a National Institute of Health Grant AM 07467 and by the Medical Research Service of the Veterans Administration (to A. V. Schally) and by a fellowship from Hoechst A. G. (to I. Torres-Aleman).",

year = "1985",

doi = "10.1016/0196-9781(85)90111-1",

language = "English (US)",

volume = "6",

pages = "463--465",

journal = "Peptides",

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T1 - Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats

AU - Debeljuk, L.

AU - Torres-Aleman, I.

AU - Schally, A. V.

N1 - Funding Information: We thank the National Hormone and Pituitary Program (NHPP) for the gifts of materials used in radioimmunoassays, Miss Martha Sampson, Mrs. Elsa Winsor and Mrs. Meredith Mason-Garcia for their excellent technical assistance and Organon Scientific, Oss Holland for the supply of ORG 30276. This work was supported by a National Institute of Health Grant AM 07467 and by the Medical Research Service of the Veterans Administration (to A. V. Schally) and by a fellowship from Hoechst A. G. (to I. Torres-Aleman).

PY - 1985

Y1 - 1985

N2 - The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.

AB - The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.

KW - LH, Pituitary

KW - LH, Prolactin

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ER -

Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats

Abstract

Keywords

ASJC Scopus subject areas

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