Abstract
The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.
| Original language | English |
|---|---|
| Pages (from-to) | 463-465 |
| Number of pages | 3 |
| Journal | Peptides |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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Keywords
- LH, Pituitary
- LH, Prolactin
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats. / Debeljuk, L.; Torres-Aleman, I.; Schally, Andrew V.
In: Peptides, Vol. 6, No. 3, 01.01.1985, p. 463-465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of an antagonistic analog of LH-RH on haloperidol-induced hyperprolactinemia in female rats
AU - Debeljuk, L.
AU - Torres-Aleman, I.
AU - Schally, Andrew V
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.
AB - The effects of prolonged treatment with the antagonistic analog of LH-RH (N-Ac-D-p-Cl-Phe1,2, D-Trp3,D-Arg6,D-Ala10) LH-RH (ORG 30276) on the hyperprolactinemia induced by haloperidol were investigated in intact or ovariectomized female rats. Treatment with ORG 30276 for 20 days significantly reduced prolactin levels elevated by daily injections of haloperidol in intact as well as in ovariectomized rats. Administration of ORG 30276 also significantly decreased serum LH levels in both types of rats. It is concluded that the LH-RH antagonist ORG 30276 is able to counteract the hyperprolactinemic effect of haloperidol. This effect might be due to a blockade of the action of endogenous LH-RH on the gonadotrophs, which results in a suppressing of the paracrine action of these cells on the lactotroph.
KW - LH, Pituitary
KW - LH, Prolactin
UR - http://www.scopus.com/inward/record.url?scp=0022203389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022203389&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(85)90111-1
DO - 10.1016/0196-9781(85)90111-1
M3 - Article
C2 - 3906589
AN - SCOPUS:0022203389
VL - 6
SP - 463
EP - 465
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 3
ER -