Effect of Amphotericin B on Adriamycin Transport in P388 Cells

Awtar Krishan, Antonieta Sauerteig, Kristie Gordon

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

In Adriamycin-sensitive and -resistant P388 cells, coincubation with amphotericin B causes a marked increase in Adriamycin retention, as determined by laser flow cytometry. P388/S cells were generally more affected than were P388/R cells. Preincubation with amphotericin B had a greater effect on Adriamycin retention than did co- or postincubation. In splenocytes, bone marrow, and ascites from mice, enhanced Adriamycin retention was seen in all the tissues. However, bone marrow cells showed heterogeneous response, with some populations being more sensitive than others.

Original languageEnglish (US)
Pages (from-to)4097-4102
Number of pages6
JournalCancer Research
Volume45
Issue number9
StatePublished - Sep 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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