Effect of amphotericin B on adriamycin transport in P388 cells

A. Krishan, A. Sauerteig, K. Gordon

Research output: Contribution to journalArticle

28 Scopus citations


In Adriamycin-sensitive and -resistant P388 cells, coincubation with amphotericin B causes a marked increase in Adriamycin retention, as determined by laser flow cytometry. P388/S cells were generally more affected than were P388/R cells. Preincubation with amphotericin B had a greater effect on Adriamycin retention than did co- or postincubation. In splenocytes, bone marrow, and ascites from mice, enhanced Adriamycin retention was seen in all the tissues. However, bone marrow cells showed heterogeneous response, with some populations being more sensitive than others.

Original languageEnglish
Pages (from-to)4097-4102
Number of pages6
JournalCancer Research
Issue number9
StatePublished - Dec 1 1985
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Krishan, A., Sauerteig, A., & Gordon, K. (1985). Effect of amphotericin B on adriamycin transport in P388 cells. Cancer Research, 45(9), 4097-4102.