TY - JOUR
T1 - Effect of Amphotericin B on Adriamycin Transport in P388 Cells
AU - Krishan, Awtar
AU - Sauerteig, Antonieta
AU - Gordon, Kristie
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1985/9/1
Y1 - 1985/9/1
N2 - In Adriamycin-sensitive and -resistant P388 cells, coincubation with amphotericin B causes a marked increase in Adriamycin retention, as determined by laser flow cytometry. P388/S cells were generally more affected than were P388/R cells. Preincubation with amphotericin B had a greater effect on Adriamycin retention than did co- or postincubation. In splenocytes, bone marrow, and ascites from mice, enhanced Adriamycin retention was seen in all the tissues. However, bone marrow cells showed heterogeneous response, with some populations being more sensitive than others.
AB - In Adriamycin-sensitive and -resistant P388 cells, coincubation with amphotericin B causes a marked increase in Adriamycin retention, as determined by laser flow cytometry. P388/S cells were generally more affected than were P388/R cells. Preincubation with amphotericin B had a greater effect on Adriamycin retention than did co- or postincubation. In splenocytes, bone marrow, and ascites from mice, enhanced Adriamycin retention was seen in all the tissues. However, bone marrow cells showed heterogeneous response, with some populations being more sensitive than others.
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M3 - Article
C2 - 4028003
AN - SCOPUS:0022409376
VL - 45
SP - 4097
EP - 4102
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 9
ER -