Effect of ammonium chloride on the astrocyte benzodiazepine receptor

Ilze Ducis, Luz Oliva B. Norenberg, Michael D. Norenberg

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We have carried out studies on the effect of ammonium chloride on the astrocyte benzodiazepine receptor. Scatchard analysis of the binding of [3H]Ro-5-4864 to homogenates prepared from primary astrocyte cultures showed a significant decrease in Kd (27% with 2 mM NH4Cl; 32% with 5 mM NH4Cl; 25% with 10 mM NH4Cl) and Bmax (14% with 10 mM NH4Cl). These findings indicate that ammonium chloride can affect the astrocyte benzodiazepine receptor, and that such receptor changes may contribute to ammonia-induced encephalopathy.

Original languageEnglish (US)
Pages (from-to)362-365
Number of pages4
JournalBrain Research
Volume493
Issue number2
DOIs
StatePublished - Jul 31 1989

Keywords

  • Ammonia
  • Astrocyte
  • Benzodiazepine receptor
  • Hepatic encephalopathy

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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