Abstract
We have carried out studies on the effect of ammonium chloride on the astrocyte benzodiazepine receptor. Scatchard analysis of the binding of [3H]Ro-5-4864 to homogenates prepared from primary astrocyte cultures showed a significant decrease in Kd (27% with 2 mM NH4Cl; 32% with 5 mM NH4Cl; 25% with 10 mM NH4Cl) and Bmax (14% with 10 mM NH4Cl). These findings indicate that ammonium chloride can affect the astrocyte benzodiazepine receptor, and that such receptor changes may contribute to ammonia-induced encephalopathy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 362-365 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 493 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 31 1989 |
Keywords
- Ammonia
- Astrocyte
- Benzodiazepine receptor
- Hepatic encephalopathy
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Ducis, I., Norenberg, L. O. B., & Norenberg, M. D. (1989). Effect of ammonium chloride on the astrocyte benzodiazepine receptor. Brain Research, 493(2), 362-365. https://doi.org/10.1016/0006-8993(89)91171-2