Effect of ammonia on cyclic AMP production in primary astrocyte cultures

David R. Liskowsky, Luz Oliva B. Norenberg, Michael D. Norenberg

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Exposure of primary astrocyte cultures to ammonia caused a dose- and time-dependent reduction of isoproterenol-stimulated cyclic AMP (cAMP) production. This treatment did not affect basal cAMP levels. This defect in receptor-linked cAMP production may contribute to the pathogenesis of hepatic and ammonia encephalopathies.

Original languageEnglish (US)
Pages (from-to)386-388
Number of pages3
JournalBrain Research
Volume386
Issue number1-2
DOIs
StatePublished - Oct 29 1986

Keywords

  • Ammonia
  • Astrocyte
  • Cyclic AMP
  • Hepatic encephalopathy
  • Isoproterenol
  • Primary culture

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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