Effect of amlodipine on mesangial cell proliferation and protein synthesis

P. J. Shultz, Leopoldo Raij

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have a definite effect on mesangial cell proliferation. We investigated whether the effects of a second generation Ca channel blocker, amlodipine, were similar. Amlodipine was found to inhibit hyperplasia and hypertrophy in mesangial cells.

Original languageEnglish
Pages (from-to)912-914
Number of pages3
JournalAmerican Journal of Hypertension
Volume5
Issue number12 I
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Amlodipine
Mesangial Cells
Cell Proliferation
Proteins
Platelet-Derived Growth Factor
Endothelins
Thrombin
Angiotensin II
Hypertrophy
Hyperplasia
Growth
Research

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of amlodipine on mesangial cell proliferation and protein synthesis. / Shultz, P. J.; Raij, Leopoldo.

In: American Journal of Hypertension, Vol. 5, No. 12 I, 01.12.1992, p. 912-914.

Research output: Contribution to journalArticle

Shultz, P. J. ; Raij, Leopoldo. / Effect of amlodipine on mesangial cell proliferation and protein synthesis. In: American Journal of Hypertension. 1992 ; Vol. 5, No. 12 I. pp. 912-914.
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