Effect of amlodipine on mesangial cell proliferation ana protein synthesis

Pamela J. Shultz, Leopoldo Raij

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have a definite effect on mesangial cell proliferation. We investigated whether the effects of a second generation Ca channel blocker, amlodipine, were similar. Amlodipine was found to inhibit hyperplasia and hypertrophy in mesangial cells.

Original languageEnglish (US)
Pages (from-to)912-914
Number of pages3
JournalAmerican journal of hypertension
Issue number12
StatePublished - Dec 1992


  • Calcium channel blocker
  • Endothelin
  • Platelet derived growth factor
  • [H]leucine
  • [H]thymidine

ASJC Scopus subject areas

  • Internal Medicine


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