Effect of amino acid infusion on the ventilatory response to hypoxia in protein-deprived neonatal piglets

Amed Soliz, Cleide Suguihara, Jian Huang, Dorothy Hehre, Eduardo Bancalari

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Several amino acids (AA) act as neurotransmitters and mediate the ventilatory response to carbon dioxide and hypoxia in adult human beings and animals. To evaluate the influence of AA on the neonatal ventilatory response to hypoxia, 29 newborn piglets less than 5 d old were randomly assigned to a control diet or protein-free diet for 7-10 d. Minute ventilation, arterial blood pressure, oxygen consumption, and arterial blood gases were measured in sedated, spontaneous breathing piglets while they breathed room air and at 1, 5 and 10 min of hypoxia (fraction of inspired oxygen concentration - 0.10) before and after 4 h of AA (Trophamine, 3 g/kg, i.v.) or 10% dextrose infusion. The administration of AA solution in protein-deprived piglets resulted in a significant increase in minute ventilation after 10 min of hypoxia (26 ± 19%) in comparison with their ventilatory response before AA infusion (10 ± 12%; p < 0.02). Similar increase in the ventilatory response to hypoxia was observed in the control diet group after AA infusion (23 ± 17% versus 11 ± 11%; p < 0.05). Changes in arterial blood pressure, oxygen consumption, and arterial blood gases during hypoxia were similar before and after AA infusion. The ventilatory response to hypoxia in both protein-free and control diet animals were similar before and after the 10% dextrose infusion. These results stress the importance of nutritional factors in the neonatal control of breathing.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalPediatric Research
Volume35
Issue number3
DOIs
StatePublished - Mar 1994

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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