Effect of alterations in ventricular rate on cardiac output in complete heart block

Philip Samet, William H. Bernstein, Aaron Medow, David A. Nathan

Research output: Contribution to journalArticle

24 Scopus citations


Evidence is presented, both from a review of the literature and from original observations in this laboratory during cardiac catheterization in man, to demonstrate that the cardiac output in the majority of patients with complete heart block can be increased with increments in ventricular rate. These data, especially when considered in conjunction with the demonstrated importance of synchronous as opposed to asynchronous atrioventricular contraction, strongly suggest that synchronous P-wave pacemakers, such as the one developed by our group, are physiologically and clinically superior to idioventricular pacemakers of either the fixed or variable rate types.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalThe American Journal of Cardiology
Issue number4
StatePublished - Oct 1964


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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